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首页> 外文期刊>Journal of Thoracic Disease >A novel risk assessment model for venous thromboembolism after major thoracic surgery: a Chinese single-center study
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A novel risk assessment model for venous thromboembolism after major thoracic surgery: a Chinese single-center study

机译：大型胸外科手术后静脉血栓栓塞的新型风险评估模型：一项中国单中心研究

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Background: Venous thromboembolism (VTE) is an insidious disease with significant morbidity and mortality. We conducted a retrospective single-center study on patients who underwent thoracic surgery and developed a novel VTE risk assessment model (RAM). Methods: Patients who underwent thoracic surgery between July 2016 and December 2017 (n=533) at the Beijing Chao-Yang Hospital were enrolled in this study. None of the patients received any prophylaxis perioperatively. Lower limbs Doppler ultrasonography was performed before and after surgery for deep venous thrombosis (DVT) confirmation. Patients with new postoperative DVT, typical symptoms of pulmonary embolism (PE), or high Caprini score (≥9) underwent further computer tomography pulmonary angiography (CTPA) examination for PE. Caprini, Rogers, Padua, and Khorana RAM were used for all of the patients. A novel RAM of VTE, which we called Chao-Yang VTE RAM, was developed according to the logistic regression analysis. Results: The overall incidence of VTE after thoracic surgery was 8.4% (45 of 533). Among the 45 VTE patients, 86.7% have DVT and 13.3% have DVT + PE. Age ≥60 (OR 4.51, 95% CI: 2.09–9.71, P=0.000) has an independent risk factor for VTE. The areas under the receiver operating characteristic (ROC) curve of Caprini, Rogers, Padua, Khorana, and Chao-Yang models were 0.74 (P Conclusions: The incidence of VTE in patients who underwent major thoracic surgery was high in our series. Based on a retrospective single-center population study, we developed a novel prediction model to identify patients receiving thoracic surgery with different risks for VTE events.
机译：背景：静脉血栓栓塞症（VTE）是一种潜伏性疾病，具有很高的发病率和死亡率。我们对接受胸外科手术的患者进行了回顾性单中心研究，并开发了新型的VTE风险评估模型（RAM）。方法：纳入2016年7月至2017年12月在北京朝阳医院接受胸外科手术的患者（n = 533）。没有患者在围手术期接受任何预防。在手术前后进行下肢多普勒超声检查以确认深静脉血栓形成（DVT）。患有新的术后DVT，典型的肺栓塞（PE）症状或Caprini评分高（≥9）的患者接受了进一步的PC断层扫描肺血管造影（CTPA）检查。 Caprini，Rogers，Padua和Khorana RAM用于所有患者。根据逻辑回归分析，开发了一种新型的VTE RAM，我们称为超阳VTE RAM。结果：胸外科手术后VTE的总发生率为8.4％（533中的45）。在45例VTE患者中，DVT为86.7％，DVT + PE为13.3％。年龄≥60岁（OR 4.51，95％CI：2.09–9.71，P = 0.000）具有独立的VTE危险因素。 Caprini，Rogers，Padua，Khorana和Chao-Yang模型的受试者工作特征（ROC）曲线下面积为0.74（P结论：在本系列的大手术中，VTE的发生率很高。基于作为一项回顾性单中心人群研究，我们开发了一种新颖的预测模型，以识别接受开胸手术且发生VTE事件风险不同的患者。

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