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首页> 外文期刊>Journal of Young Pharmacists >Cationic Guar Gum Poly Electrolytecomplex-Microparticles
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Cationic Guar Gum Poly Electrolytecomplex-Microparticles

机译：阳离子瓜尔胶聚电解质复合物微粒

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Aim: The aim of this study was to organize polyelectrolyte complex microparticles (PECMP) of cationic guar gum and xanthan gum. Materials and Methods: The complex formed was loaded with diclofenac sodium (DS) as a model drug. The prepared microparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning colorimetry (DSC), scanning electron microscopy (SEM), and evaluated for in vivo in vitro properties. Result: DSC and FT-IR studies were done to measure the formation of PEC and confirmed the absence of chemical interactions between drug and polymers. By SEM, the surface morphology was studied. Particle size ranged between 294 and 300 μm. The percentage of encapsulation efficiency of the microparticles was found to be 96.47%. In vitro release studies indicated that the drug release extended beyond 12 h. Kinetic analysis of dissolution data indicated that the drug release was by super case II mechanisms. Compared with DS solution, microparticles show low and prolonged drug release when subjected to in vivo pharmacokinetic evaluation in rabbits. Based on in vitro and in vivo studies, it was concluded that these micro particles provided oral controlled release of DS. Conclusion: The research findings obtained from the studies were found to be satisfactory. Hence, PECMP can be effectively used for preparation of sustained-release formulation.
机译：目的：本研究的目的是组织阳离子瓜尔胶和黄原胶的聚电解质复合微粒（PECMP）。材料和方法：形成的复合物装有双氯芬酸钠（DS）作为模型药物。通过傅立叶变换红外光谱（FT-IR），差示扫描比色法（DSC），扫描电子显微镜（SEM）表征制备的微粒，并评估其体内体外性能。结果：进行了DSC和FT-IR研究以测量PEC的形成，并证实了药物与聚合物之间不存在化学相互作用。通过SEM，研究了表面形态。粒度范围为294至300μm。发现微粒的包封效率百分比为96.47％。体外释放研究表明药物释放延长了超过12小时。溶出度数据的动力学分析表明，药物释放是通过超级案例II机制引起的。与DS溶液相比，微粒在兔子体内进行药代动力学评估时显示出较低且延长的药物释放。根据体外和体内研究，可以得出结论，这些微粒提供了DS的口服控制释放。结论：从研究中获得的研究结果被认为是令人满意的。因此，PECMP可以有效地用于制备缓释制剂。

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