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首页> 外文期刊>Journal of Translational Medicine >Comparison of 68 Ga-PSMA-11 PET-CT with mpMRI for preoperative lymph node staging in patients with intermediate to high-risk prostate cancer
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Comparison of 68 Ga-PSMA-11 PET-CT with mpMRI for preoperative lymph node staging in patients with intermediate to high-risk prostate cancer

机译：68 Ga-PSMA-11 PET-CT与mpMRI对中高危前列腺癌患者术前淋巴结分期的比较

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To evaluate the diagnostic value of 68Ga-PSMA-11 PET-CT with multiparametric magnetic resonance imaging (mpMRI) for lymph node (LN) staging in patients with intermediate- to high-risk prostate cancer (PCa) undergoing radical prostatectomy (RP) with pelvic lymph node dissection (PLND). We retrospectively identified 42 consecutive patients with intermediate- to high-risk PCa according to D′Amico and without concomitant cancer. Preoperative 68Ga-PSMA-11 PET-CT, pelvic mpMRI and subsequent robot assisted laparoscopic RP with PLND were performed in all patients. Among 42 patients assessed, the preoperative PSA value, Gleason score, pT stage and intraprostatic PCa volume of patients with LN metastases were all significantly higher than those without metastases (P?=?0.029, 0.028, 0.004, respectively). The average maximum standardized uptake value (SUV) of 68Ga-PSMA-11 PET-CT positive PCa of patients with or without LN metastases were 13.10 (range 6.12–51.75) and 7.22 (range 5.4–11.2), respectively (P?
机译：通过多参数磁共振成像（mpMRI）评估68Ga-PSMA-11 PET-CT对接受前列腺癌根治术（RP）的中高危前列腺癌（PCa）患者的淋巴结分期（LN）的诊断价值盆腔淋巴结清扫术（PLND）。我们回顾性地根据D'Amico连续鉴定了42例中至高危PCa且无伴随癌症的患者。所有患者均进行术前68Ga-PSMA-11 PET-CT，盆腔mpMRI以及随后的机器人辅助腹腔镜RP PLND检查。在接受评估的42例患者中，患有LN转移的患者的术前PSA值，Gleason评分，pT分期和前列腺内PCa量均显着高于无转移的患者（分别为P = 0.029、0.028、0.004）。有或没有LN转移的患者68Ga-PSMA-11 PET-CT阳性PCa的平均最大标准化摄取值（SUV）分别为13.10（范围6.12–51.75）和7.22（范围5.4–11.2）（P ？ 0.001）。 68Ga-PSMA-11 PET-CT和骨盆mpMRI能够成功对所有42例患者进行术前明确的准确诊断和准确定位。 15例患者（35.71％）患有pN1分期。发现51个阳性LN。 68Ga-PSMA-11 PET-CT和骨盆mpMRI均显示出出色的基于患者和基于区域的敏感性，特异性，阴性预测值和阳性预测值。在68Ga-PSMA-11 PET-CT和mpMRI之间，根据LNM的直径检测LNM并没有统计学差异。 68Ga-PSMA-11 PET-CT和mpMRI对接受PLND RP的中高危PCa患者的LN分期均具有重要价值。然而，尽管68Ga-PSMA-11 PET-CT具有出色的性能，但它不能代替对于淋巴结分期仍然出色的mpMRI。

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