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首页> 外文期刊>Journal of Radiation Research >Dosimetric evaluation of the heart and left anterior descending artery dose in radiotherapy for Japanese patients with breast cancer
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Dosimetric evaluation of the heart and left anterior descending artery dose in radiotherapy for Japanese patients with breast cancer

机译：日本乳腺癌患者放射治疗中心脏和左前降支剂量的剂量学评估

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Intensity-modulated radiotherapy (IMRT) has been used for breast cancer as well as in field-in-field techniques. Few dosimetric comparison studies have been conducted using IMRT and volumetric modulated arc therapy (VMAT) for Japanese patients. We aimed to study such patients. Thirty-two patients with left-sided breast cancer were enrolled. We conducted the following five treatment plans: two field-static IMRT (2F-S-IMRT), four field-static IMRT (4F-S-IMRT), 40 degrees dual partial arc VMAT (40d-VMAT), 80 degrees dual partial arc VMAT (80d-VMAT) and 210 degrees partial VMAT (210p-VMAT). We evaluated the following: level of coverage of planning target volume (PTV) of 95% for irradiation at a dose of 50 Gy (D95) and the percentage of the heart and left anterior descending artery (LAD) volume that received 10 Gy or more (V10). As a result, the coverage of 40d-VMAT for the prescribed PTV dose of D95 was significantly lower than that of the other treatment plans (P < 0.05). Regarding heart V10 and LAD V10, 2F-S-IMRT, 40d-VMAT and 80d-VMAT showed significantly lower dose than the other treatment plans (P < 0.05). In conclusion, among the five plans, 2F-S-IMRT is recommended for Japanese patients because of high coverage of D95 of PTV, low V10 of the heart and LAD and the monitor unit value was the lowest.
机译：调强放射疗法（IMRT）已用于乳腺癌以及田间技术。很少有针对日本患者使用IMRT和容积调制电弧疗法（VMAT）进行剂量学比较研究。我们旨在研究这类患者。纳入了32例左侧乳腺癌患者。我们执行了以下五个治疗计划：两个场静态IMRT（2F-S-IMRT），四个场静态IMRT（4F-S-IMRT），40度双部分弧形VMAT（40d-VMAT），80度双部分弧形VMAT弧形VMAT（80d-VMAT）和210度局部VMAT（210p-VMAT）。我们评估了以下内容：剂量为50 Gy（D95）时，辐射的计划目标体积（PTV）的覆盖度为95％，接受了10 Gy或更多的心脏和左前降支动脉（LAD）体积的百分比（V10）。结果，D95处方PTV剂量的40d-VMAT覆盖率显着低于其他治疗计划（P <0.05）。关于心脏V10和LAD V10，2F-S-IMRT，40d-VMAT和80d-VMAT的剂量显着低于其他治疗方案（P <0.05）。总之，在这五个计划中，由于PTV的D95覆盖率高，心脏的V10和LAD值低，并且监护仪单位值最低，因此建议日本患者使用2F-S-IMRT。

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