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首页> 外文会议>World Congress on Medical Physics and Biomedical Engineering >Dosimetric impact of accurately delineating of the left anterior descending artery in photon and proton radiotherapy
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Dosimetric impact of accurately delineating of the left anterior descending artery in photon and proton radiotherapy

机译：精确描绘左前期下降动脉精确描绘光子和质子放射治疗的剂量造成的影响

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The dosimetric impact of accurately delineating the left anterior descending artery (LAD) was investigated for routine treatment planning deep inspiration breath-hold (DIBH) CT where cardiac motion was not accounted for. The LAD was contoured in the routine DIBH CT images by an expert radiologist in a population of 10 patients with cancer of the left breast. The motion blurring of the LAD in the DIBH CT images was extracted from the contoured LAD to create a corrected LAD volume. This was used to compare the maximum and mean LAD dose over 3D conformal radiotherapy (3DCRT), uniform scattering (US) proton, and pencil beam scanning (PBS) proton plans. Using a corrected LAD volume reduced the maximum dose LAD DVH indicator by 2% (3DCRT), 4% (US), and 25% (PBS). A corrected LAD volume increased the mean dose LAD DVH indicator by 25% (3DCRT), 61% (US), and 35% (PBS). In terms of absolute dose the impact of contouring on LAD is higher for photon therapy due to the higher doses delivered using this modality. Overall, the results demonstrate that the LAD volume could potentially be the source of inconsistencies in correlation between dose and radiation-induced cardiac toxicity when uncompensated motion is present in the treatment planning images.
机译：的准确划定剂量测定冲击左前降支动脉（LAD）进行了研究用于常规治疗计划深吸气屏气（DIBH）CT其中心脏运动没有算。小伙子在左乳腺癌10名患者的一群患者中，通过专家放射科学家在常规DIBH CT图像中。从轮廓垫中提取DIBH CT图像中的LAD的运动模糊以产生校正的LAD体积。这用于比较3D全成形放射疗法（3DCRT），均匀散射（US）质子和铅笔扫描（PBS）质子计划的最大和平均小伙子剂量。使用校正的LAD卷将最大剂量矮化DVH指示灯减少2％（3DCRT），4％（美国）和25％（PBS）。校正的小伙子体积将平均剂量LAD DVH指示器增加25％（3DCRT），61％（美国）和35％（PBS）。在绝对剂量方面，由于使用这种模态递送的较高剂量，光子疗法对LAD的角落对LAD的影响更高。总的来说，结果表明，当在治疗计划图像中存在未补偿的运动时，LAD体积可能是剂量和辐射诱导的心脏毒性之间的相关性的源。

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