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首页> 外文期刊>Journal of Research in Medical and Dental Science >Investigation And Comparison Of The Effect Of Saffron Petals Hydroalcoholic Extract With Metformin And Glibenclamide On Serum Glucose, HbA1c And Insulin Levels In Streptozotocin-Induced Diabetic Rats
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Investigation And Comparison Of The Effect Of Saffron Petals Hydroalcoholic Extract With Metformin And Glibenclamide On Serum Glucose, HbA1c And Insulin Levels In Streptozotocin-Induced Diabetic Rats

机译：藏红花花瓣水醇提取物与二甲双胍和格列本脲对链脲佐菌素诱导的糖尿病大鼠血清葡萄糖，HbA1c和胰岛素水平影响的比较

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Introduction: Chemical drugs administered to control and treat diabetes mellitus are mostly with side effects and this has caused a daily increasing expansion in the use of alternative treatment methods including medicinal herbs. The present study has been conducted to investigate the effect of saffron petal hydroalcoholic extract on serum glucose, insulin and glycosylated hemoglobin (HbA1c) levels and compare it with the effects of metformin and glibenclamide in diabetes-induced rats. Materials and Methods: A total number of 35 male Wistar rats (200 ± 20 g) were assigned to seven 5-animal groups: control group (normal), diabetic group (Streptozotocin 60 mg/kg/body weight) and five other diabetic groups (receiving saffron petals hydroalcoholic extract in 100, 200 and 300 mg/kg doses and glibenclamide in 5 mg/kg and metformin in 500 mg/kg, respectively). The experiment lasted eight weeks and blood samples were collected from all the rats in the end of the study. Results: 100 and 200 mg/kg dosages of saffron petal extract caused significant reductions in serum glucose levels in contrast to the diabetic groups (P0.01 and P0.05, respectively). All three dosages of saffron petals extract, 100, 200 and 300 mg/ kg, were found significantly reducing serum HbA1c level in diabetic groups as well as significantly increasing serum insulin level (P0.001, P0.001 and P0.05, respectively). The diabetic groups treated with glibenclamide and metformin, as well, brought about significant reductions in serum glucose and HbA1c levels (P0.01 and P0.001, respectively) and significant increase in serum insulin levels (P0.001). Results: 100 and 200 mg/kg dosages of saffron petal extract caused significant reductions in serum glucose levels in contrast to the diabetic groups (P0.01 and P0.05, respectively). All three dosages of saffron petals extract, 100, 200 and 300 mg/ kg, were found significantly reducing serum HbA1c level in diabetic groups as well as significantly increasing serum insulin level (P0.001, P0.001 and P0.05, respectively). The diabetic groups treated with glibenclamide and metformin, as well, underwent significant reductions in serum glucose and HbA1c levels (P0.01 and P0.001, respectively) and significant increase in serum insulin levels (P0.001). The impact rate of saffron petal extract administered in a dosage of 100 mg/kg on serum insulin level elevation was higher than such drugs as glibenclamide and metformin. Conclusion: Saffron petal, like glibenclamide and metformin, is interestingly capable of influencing high serum levels of glucose and HbA1c and insulin, especially in low dosages, and it can be an appropriate solution to the control of diabetes.
机译：简介：用来控制和治疗糖尿病的化学药品大多具有副作用，这已导致使用包括草药在内的其他治疗方法的使用日益增加。本研究旨在研究藏红花花瓣水醇提取物对糖尿病大鼠血清葡萄糖，胰岛素和糖基化血红蛋白（HbA1c）水平的影响，并将其与二甲双胍和格列本脲的作用进行比较。材料和方法：将35只雄性Wistar大鼠（200±20 g）分为7个5动物组：对照组（正常），糖尿病组（链脲佐菌素60 mg / kg /体重）和其他五个糖尿病组（分别以100、200和300 mg / kg剂量的藏红花花瓣水醇提取物和5 mg / kg的格列本脲和500 mg / kg的二甲双胍）。实验持续了八周，并在研究结束时从所有大鼠中采集了血液样本。结果：与糖尿病组相比，番红花花瓣提取物的剂量为100和200 mg / kg导致血清葡萄糖水平显着降低（分别为P <0.01和P <0.05）。发现三种剂量的藏红花花瓣提取物（100、200和300 mg / kg）可显着降低糖尿病组的血清HbA1c水平，并显着提高血清胰岛素水平（分别为P <0.001，P <0.001和P <0.05） 。格列本脲和二甲双胍治疗的糖尿病组也使血糖和HbA1c水平显着降低（分别为P <0.01和P <0.001），并且血清胰岛素水平也显着提高（P <0.001）。结果：与糖尿病组相比，番红花花瓣提取物的剂量为100和200 mg / kg导致血清葡萄糖水平显着降低（分别为P <0.01和P <0.05）。发现三种剂量的藏红花花瓣提取物（分别为100、200和300 mg / kg）可显着降低糖尿病组的血清HbA1c水平，并显着提高血清胰岛素水平（分别为P <0.001，P <0.001和P <0.05） 。格列苯脲和二甲双胍治疗的糖尿病组的血糖和HbA1c水平也显着降低（分别为P <0.01和P <0.001），血清胰岛素水平也显着提高（P <0.001）。番红花花瓣提取物以100 mg / kg的剂量给药对血清胰岛素水平升高的影响率高于格列本脲和二甲双胍等药物。结论：藏红花花瓣，如格列本脲和二甲双胍，能够影响高血清葡萄糖，HbA1c和胰岛素水平，尤其是低剂量时，它可能是控制糖尿病的合适方法。

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