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首页> 外文期刊>BMC Genomics >Functional requirements driving the gene duplication in 12 Drosophila species
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Functional requirements driving the gene duplication in 12 Drosophila species

机译：功能需求驱动12个果蝇物种中的基因复制

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Background Gene duplication supplies the raw materials for novel gene functions and many gene families arisen from duplication experience adaptive evolution. Most studies of young duplicates have focused on mammals, especially humans, whereas reports describing their genome-wide evolutionary patterns across the closely related Drosophila species are rare. The sequenced 12 Drosophila genomes provide the opportunity to address this issue. Results In our study, 3,647 young duplicate gene families were identified across the 12 Drosophila species and three types of expansions, species-specific, lineage-specific and complex expansions, were detected in these gene families. Our data showed that the species-specific young duplicate genes predominated (86.6%) over the other two types. Interestingly, many independent species-specific expansions in the same gene family have been observed in many species, even including 11 or 12 Drosophila species. Our data also showed that the functional bias observed in these young duplicate genes was mainly related to responses to environmental stimuli and biotic stresses. Conclusions This study reveals the evolutionary patterns of young duplicates across 12 Drosophila species on a genomic scale. Our results suggest that convergent evolution acts on young duplicate genes after the species differentiation and adaptive evolution may play an important role in duplicate genes for adaption to ecological factors and environmental changes in Drosophila.
机译：背景技术基因复制为新的基因功能提供了原材料，而复制产生的许多基因家族经历了适应性进化。对年轻复制品的大多数研究都集中在哺乳动物，特别是人类上，而很少有报道描述它们在紧密相关的果蝇物种中的全基因组进化模式。测序的12个果蝇基因组提供了解决这个问题的机会。结果在我们的研究中，在12个果蝇物种中鉴定出3647个年轻的重复基因家族，并在这些基因家族中检测到三种类型的扩增，即物种特异性，谱系特异性和复杂性扩增。我们的数据表明，物种特异性的年轻重复基因比其他两种类型占主导（86.6％）。有趣的是，在许多物种中，甚至包括11或12个果蝇物种，都观察到了同一基因家族中许多独立的物种特异性扩展。我们的数据还表明，在这些年轻的重复基因中观察到的功能偏差主要与对环境刺激和生物胁迫的反应有关。结论本研究揭示了在基因组规模上跨越12个果蝇物种的年轻复制品的进化模式。我们的结果表明，物种分化和适应性进化后，收敛进化作用于年轻的重复基因，可能在重复基因中对果蝇的生态因子和环境变化的适应起了重要作用。

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