Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

Pavel A Karpov; Elena S Nadezhdina; Alla I Yemets; Vadym G Matusov; Alexey Yu Nyporko; Nadezhda Yu Shashina; Yaroslav B Blume

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Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

机译：植物微管和细胞周期相关的丝氨酸-苏氨酸蛋白激酶的生物信息学搜索

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A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

机译：对涉及细胞分裂和微管蛋白磷酸化调控的人丝氨酸-苏氨酸蛋白激酶的植物同源物（SLK，PAK6，PAK7，MARK1，MAST2，TTBK1，TTBK2，AURKA，PLK1，PLK4和PASK）进行了生物信息学搜索。鉴定了许多SLK，MAST2和AURKA植物同源物。人AURKA激酶的最接近鉴定的同源物是功能未知的蛋白，来自葡萄（Vitis vinifera）的A7PY12 / GSVIVT00026259001（在本文中被称为“ STALK”，丝氨酸-苏氨酸-极光样激酶）。对STALK三维结构的分析证实了其与AURKA样蛋白激酶亚组的关系。

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《BMC Genomics》 |2010年第1期|共页
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Pavel A Karpov; Elena S Nadezhdina; Alla I Yemets; Vadym G Matusov; Alexey Yu Nyporko; Nadezhda Yu Shashina; Yaroslav B Blume;
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中图分类医学遗传学;
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1. Bioinformatic Search of Plant Protein Kinases Involved in the Phosphorylation of Microtubular Proteins and the Regulation of the Cell Cycle [J] . P. A. Karpov, E. S. Nadezhdina, A. I. Emets, Cytology and genetics . 2009,第3期

机译：植物蛋白激酶参与微管蛋白磷酸化和细胞周期调控的生物信息学搜索。
2. h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells [J] . Waldegger S., Barth P., Fillon S., Cellular Physiology and Biochemistry . 2000,第4期

机译：h-sgk丝氨酸-苏氨酸蛋白激酶作为HepG2人肝癌细胞中p38 / MAP激酶途径的转录靶标
3. Bioinformatic Search for Ca~(2+)- and Calmodulin-Dependent Protein Kinases Potentially Associated with the Regulation of Plant Cytoskeleton [J] . Novozhylov D. O., Karpov P. A., Blume Ya. B. Cytology and genetics . 2017,第4期

机译：Ca〜（2+）和钙调蛋白依赖性蛋白激酶的生物信息学搜索可能与植物细胞骨架的调节相关。
4. MAP Kinases in Plant Signal Transduction: Versatile Tools for Signaling Stress, Cell Cycle, and More [C] . Claudia Jonak, Stefan Kiegerl, Wilco Ligterink, NATO advanced research workshop on plant tolerance to abiotic stresses in agriculture: Role of genetic engineering . 2000

机译：植物信号转导中的Map Kinases：通知应力，细胞周期等的多功能工具
5. Cell cycle inhibition as a mode of abnormal development: The role of cell cycle checkpoint proteins and cyclin-dependent kinase inhibitors in neurodevelopmental toxicant defense. [D] . Gribble, Elizabeth J. 2005

机译：细胞周期抑制是异常发育的一种方式：细胞周期检查点蛋白和细胞周期蛋白依赖性激酶抑制剂在神经发育毒物防御中的作用。
6. Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases [O] . Pavel A Karpov, Elena S Nadezhdina, Alla I Yemets, 2010

机译：植物微管和细胞周期相关的丝氨酸-苏氨酸蛋白激酶的生物信息学搜索
7. Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases [O] . Pavel A Karpov, Elena S Nadezhdina, Alla I Yemets, 2010

机译：植物微管和细胞周期相关的丝氨酸-苏氨酸蛋白激酶的生物信息学搜索

Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

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