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Bioinformatic Search of Plant Protein Kinases Involved in the Phosphorylation of Microtubular Proteins and the Regulation of the Cell Cycle

机译:植物蛋白激酶参与微管蛋白磷酸化和细胞周期调控的生物信息学搜索。

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摘要

The bioinformatic search of the plant homologues of human protein kinases SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK2, and PASK, involved in the phosphorylation of microtubular proteins and regulation of cell division, was carried out. The plant homologues of protein kinases SLK, MAST2, and AURKA were identified. It was found that the closest homologue of human protein kinase AURKA is a protein A7PY12_VITVI (STALK, Serine-Threonine Aurora-Like Kinase) from grapes (Vitis vin-ifera), whose function is still unknown. The reconstruction and analysis of the 3D-structure of the STALK protein confirmed its relation to the group of AURKA-like protein kinases.
机译:对人类蛋白激酶SLK,PAK6,PAK7,MARK1,MAST2,TTBK1,TTBK2,AURKA,PLK1,PLK2和PASK的植物同源物进行了生物信息学搜索,这些蛋白参与了微管蛋白的磷酸化和细胞分裂的调控。 。鉴定了蛋白激酶SLK,MAST2和AURKA的植物同源物。发现人类蛋白激酶AURKA的最接近同源物是来自葡萄(Vitis vin-ifera)的蛋白A7PY12_VITVI(STALK,丝氨酸-苏氨酸-Aurora样激酶),其功能尚不清楚。 STALK蛋白3D结构的重建和分析证实了它与AURKA样蛋白激酶的关系。

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  • 来源
    《Cytology and genetics》 |2009年第3期|201-215|共15页
  • 作者单位

    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kiev, Ukraine;

    Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow region, Russia Moscow State University, Moscow, Russia;

    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kiev, Ukraine;

    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kiev, Ukraine;

    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kiev, Ukraine;

    Moscow State University, Moscow, Russia;

    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kiev, Ukraine;

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