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首页> 外文期刊>BMC Genomics >Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC
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Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC

机译：与老年肝细胞癌相比，年轻的肝细胞癌（HCC）丧失了肝细胞生成程序并增加了胚胎干细胞性状

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Background Hepatocellular carcinoma (HCC) in young subjects is rare but more devastating. We hypothesize that genes and etiological pathways are unique to young HCC (yHCC; ≤40?years old at diagnosis) patients. We therefore compared the gene expression profiles between yHCCs and HCCs from elderly patients. Results All 44 young HCCs (≤40?years old at the diagnosis; 23 cases in the training set while another 21 in the validation cohort) were positive for serum hepatitis B surface antigen (HBsAg), but negative for antibodies to hepatitis C virus (anti-HCV). All 48 elderly (>40?years old; 38 in the training set while another 10 in the validation cohort) HCC patients enrolled were also serum HBsAg positive and anti-HCV negative. Comparative genomics analysis was further performed for elucidating enriched or suppressed biological activities in different HCC subtypes. The yHCC group showed more macroscopic venous invasions (60.9% vs. 10.5%, p?Conclusion This study revealed the molecular makeup of yHCC and the link between ESC traits and HCC subtypes. Findings in elderly tumors, therefore, cannot be simply extrapolated to young patients, and yHCC should be treated differently.
机译：背景年轻人中的肝细胞癌（HCC）很少见，但更具破坏性。我们假设基因和病因途径是年轻的HCC（yHCC;诊断时≤40岁）所特有的。因此，我们比较了老年患者的yHCC和HCC之间的基因表达谱。结果所有44例年轻HCC（诊断时≤40岁;在培训组中为23例，在验证队列中为21例）的血清乙型肝炎表面抗原（HBsAg）均为阳性，但对丙型肝炎病毒的抗体为阴性（抗HCV）。入组的所有48名老年人（> 40岁;在培训组中为38名，在验证队列中为另外10名）HCC患者的血清HBsAg阳性和抗HCV阴性。进一步进行了比较基因组分析，以阐明不同HCC亚型中富集或抑制的生物学活性。 yHCC组表现出更多的宏观静脉浸润（60.9％vs. 10.5％，p？结论）该研究揭示了yHCC的分子组成以及ESC特性与HCC亚型之间的联系，因此，不能简单地将老年肿瘤的发现外推到年轻患者和yHCC应该区别对待。

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