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首页> 外文期刊>BMC Genomics >Analysis of genomic rearrangements, horizontal gene transfer and role of plasmids in the evolution of industrial important Thermus species
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Analysis of genomic rearrangements, horizontal gene transfer and role of plasmids in the evolution of industrial important Thermus species

机译：基因组重排，水平基因转移以及质粒在重要重要Thermus物种进化中的作用分析

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Background Bacteria of genus Thermus inhabit both man-made and natural thermal environments. Several Thermus species have shown biotechnological potential such as reduction of heavy metals which is essential for eradication of heavy metal pollution; removing of organic contaminants in water; opening clogged pipes, controlling global warming among many others. Enzymes from thermophilic bacteria have exhibited higher activity and stability than synthetic or enzymes from mesophilic organisms. Results Using Meiothermus silvanus DSM 9946 as a reference genome, high level of coordinated rearrangements has been observed in extremely thermophilic Thermus that may imply existence of yet unknown evolutionary forces controlling adaptive re-organization of whole genomes of thermo-extremophiles. However, no remarkable differences were observed across species on distribution of functionally related genes on the chromosome suggesting constraints imposed by metabolic networks. The metabolic network exhibit evolutionary pressures similar to levels of rearrangements as measured by the cross-clustering index. Using stratigraphic analysis of donor-recipient, intensive gene exchanges were observed from Meiothermus species and some unknown sources to Thermus species confirming a well established DNA uptake mechanism as previously proposed. Conclusion Global genome rearrangements were found to play an important role in the evolution of Thermus bacteria at both genomic and metabolic network levels. Relatively higher level of rearrangements was observed in extremely thermophilic Thermus strains in comparison to the thermo-tolerant Thermus scotoductus. Rearrangements did not significantly disrupt operons and functionally related genes. Thermus species appeared to have a developed capability for acquiring DNA through horizontal gene transfer as shown by the donor-recipient stratigraphic analysis.
机译：背景Thermus属的细菌居住在人造和自然热环境中。几种Thermus物种已显示出生物技术潜力，例如减少重金属，这对于消除重金属污染至关重要;去除水中的有机污染物;打开堵塞的管道，控制全球变暖。来自嗜热细菌的酶比来自嗜温生物的酶或合成酶具有更高的活性和稳定性。结果使用Meiothermus silvanus DSM 9946作为参考基因组，已在极嗜热的Thermus中观察到高水平的协调重排，这可能意味着存在未知的进化力，这些进化力控制了嗜热嗜热菌整个基因组的适应性重组。然而，在染色体上功能相关基因的分布上，物种间未观察到显着差异，表明代谢网络施加了限制。代谢网络表现出的进化压力类似于通过交叉聚类指数测得的重排水平。使用供体-受体的地层学分析，观察到了从迈奥特莫斯菌属（Meiothermus）种和热栖菌（Thermus）种的一些未知来​​源的密集基因交换，证实了先前提出的良好建立的DNA摄取机制。结论发现在基因组和代谢网络水平上，全球基因组重排在栖热菌的进化中起着重要作用。与耐热的Thermus scotoductus相比，在极端嗜热的Thermus菌株中观察到相对较高的重排水平。重排没有显着破坏操纵子和功能相关基因。如供体-受体地层分析所示，Thermus物种似乎具有通过水平基因转移获得DNA的能力。

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