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首页> 外文期刊>BMJ Open >Relationship between diagonal earlobe creases and coronary artery disease as determined via angiography
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Relationship between diagonal earlobe creases and coronary artery disease as determined via angiography

机译：通过血管造影确定对角耳垂褶皱与冠状动脉疾病之间的关系

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Objective This study was designed to examine the prevalence of unilateral and bilateral diagonal earlobe creases (DELCs) with respect to the diagnosis of coronary heart disease (CHD). Methods A total of 558 consecutive participants (402 males and 156 females) aged 36–91?years who underwent coronary angiography were enrolled in this study. The participants were classified as being without a DELC, having a unilateral DELC and having bilateral DELCs; participants with either a unilateral DELC or bilateral DELCs were defined as participants with DELCs. Significant CHD was defined as at least one major vessel with 50% stenosis, and coronary atherosclerosis severity was defined using the Gensini scoring system. Results In the present study, bilateral DELCs were more frequently among male (p=0.001), CHD (p=0.000), older people (p=0.000) and those with more severe coronary artery atherosclerosis (p=0.000). The results of the multiple regression analyses indicated that DELCs (OR, 4.861; 95% CI 3.093 to 7.642, p=0.000) remained independently associated with a risk of CHD. It was assumed that participants without a DELC have a certain background risk for CHD (OR is assumed to be 1); the results of the multivariate logistic regression indicated that the relative risk of CHD among participants with bilateral DELCs was 5.690 among all participants (OR, 5.690; 95% CI 3.450 to 9.384, p=0.000), 5.436 among male participants (OR, 5.436; 95% CI 2.808 to 10.523, p=0.000) and 7.148 among female participants (OR, 7.148; 95% CI 3.184 to 16.049, p=0.000). Moreover, a positive association between DELC and age (SI=1.21, SIM=1.65, AP =0.132), gender (SI=2.09, SIM=0.81, AP=0.49) and smoking status (SI=1.49, SIM=0.73, AP=0.29) was found, respectively. Conclusions The results of the present study indicated that DELCs are a simple and a feasible means of identifying CHD. However, the exact mechanism underlying the relationship between DELCs and CHD warrants further study.
机译：目的本研究旨在检查单侧和双侧对角耳垂折痕（DELC）在诊断冠心病（CHD）方面的患病率。方法本研究共纳入36〜91岁的558名连续参与者（男性402名，女性156名），接受冠状动脉造影。参与者被分类为不具有DELC，具有单侧DELC和具有双侧DELC。具有单侧DELC或双侧DELC的参与者被定义为具有DELC的参与者。冠心病的严重程度定义为至少一条狭窄程度大于50％的主要血管，并使用Gensini评分系统定义冠状动脉粥样硬化的严重程度。结果在本研究中，男性（p = 0.001），冠心病（p = 0.000），老年人（p = 0.000）和患有更严重的冠状动脉粥样硬化的人（p = 0.000）的双侧DELCs更为常见。多元回归分析的结果表明，DELCs（OR，4.861; 95％CI 3.093至7.642，p = 0.000）仍与CHD风险独立相关。假设没有DELC的参与者有一定的CHD背景风险（或假设为1）;多元logistic回归分析结果显示，双侧DELCs参与者中CHD的相对风险在所有参与者中为5.690（OR，5.690; 95％CI 3.450至9.384，p = 0.000），在男性参与者中为5.436（OR，5.436;女性参与者中95％CI 2.808至10.523，p = 0.000）和7.148（OR，7.148; 95％CI 3.184至16.049，p = 0.000）。此外，DELC与年龄（SI = 1.21，SIM = 1.65，AP = 0.132），性别（SI = 2.09，SIM = 0.81，AP = 0.49）和吸烟状况（SI = 1.49，SIM = 0.73，AP）之间呈正相关= 0.29）。结论本研究的结果表明，DELCs是鉴定CHD的简单可行的方法。然而，DELC和CHD之间关系的确切机制值得进一步研究。

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