...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Genomics >Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update
【24h】

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

机译：自发性早产和单核苷酸基因多态性：最近更新

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Preterm birth (PTB), birth at Results A comprehensive evaluation of studies on SNPs known to confer potential risk of PTB was done by performing a targeted PubMed search for the years 2007–2015 and systematically reviewing all relevant studies. Evaluation of 92 studies identified 119 candidate genes with SNPs that had potential association with PTB. The genes were associated with functions of a wide spectrum of tissue and cell types such as endocrine, tissue remodeling, vascular, metabolic, and immune and inflammatory systems. Conclusions A number of potential functional candidate gene variants have been reported that predispose women for PTB. Understanding the complex genomic landscape of PTB needs high-throughput genome sequencing methods such as whole-exome sequencing and whole-genome sequencing approaches that will significantly enhance the understanding of PTB. Identification of high risk women, avoidance of possible risk factors, and provision of personalized health care are important to manage PTB.
机译：背景早产（PTB），结果出生通过对2007-2015年进行的有针对性的PubMed搜索并系统地回顾所有相关研究，对已知具有PTB潜在风险的SNPs进行了综合评估。对92项研究的评估确定了119个具有SNP的候选基因，这些基因可能与PTB相关。这些基因与多种组织和细胞类型的功能有关，例如内分泌，组织重塑，血管，代谢，免疫和炎症系统。结论据报道，许多潜在的功能候选基因变异使女性易患PTB。了解PTB的复杂基因组格局需要高通量的基因组测序方法，例如全外显子组测序和全基因组测序方法，这将大大增强对PTB的理解。识别高危妇女，避免可能的危险因素以及提供个性化的医疗保健对于管理PTB至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号