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首页> 外文期刊>BMC Public Health >Life-course origins of social inequalities in adult immune cell markers of inflammation in a developing southern Chinese population: the Guangzhou Biobank Cohort Study
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Life-course origins of social inequalities in adult immune cell markers of inflammation in a developing southern Chinese population: the Guangzhou Biobank Cohort Study

机译：中国南方发展中国家成年人炎症的成人免疫细胞标志物社会不平等的生命历程根源：广州生物银行队列研究

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Background Socioeconomic position (SEP) throughout life is associated with cardiovascular disease, though the mechanisms linking these two are unclear. It is also unclear whether there are critical periods in the life course when exposure to better socioeconomic conditions confers advantages or whether SEP exposures accumulate across the whole life course. Inflammation may be a mechanism linking socioeconomic position (SEP) with cardiovascular disease. In a large sample of older residents of Guangzhou, in southern China, we examined the association of life course SEP with inflammation. Methods In baseline data on 9,981 adults (≥ 50 years old) from the Guangzhou Biobank Cohort Study (2006-08), we used multivariable linear regression and model fit to assess the associations of life course SEP at four stages (childhood, early adult, late adult and current) with white blood, granulocyte and lymphocyte cell counts. Results A model including SEP at all four life stages best explained the association of life course SEP with white blood and granulocyte cell count for men and women, with early adult SEP (education) making the largest contribution. A critical period model best explained the association of life course SEP with lymphocyte count, with sex-specific associations. Early adult SEP was negatively associated with lymphocytes for women. Conclusions Low SEP throughout life may negatively impact late adult immune-inflammatory status. However, some aspects of immune-inflammatory status may be sensitive to earlier exposures, with sex-specific associations. The findings were compatible with the hypothesis that in a developing population, upregulation of the gonadotropic axis with economic development may obscure the normally protective effects of social advantage for men.
机译：背景技术整个生命中的社会经济地位（SEP）与心血管疾病有关，尽管将两者联系起来的机制尚不清楚。还不清楚在生命历程中是否有关键的时期，暴露于更好的社会经济条件会带来好处，或者在整个生命历程中是否累积了SEP暴露。炎症可能是将社会经济地位（SEP）与心血管疾病联系起来的一种机制。在中国南方广州市的一大批老年人中，我们研究了生命周期SEP与炎症的关系。方法根据广州生物银行队列研究（2006-08）的9,981名成年人（≥50岁）的基线数据，我们使用多元线性回归和模型拟合评估了生命过程SEP在四个阶段（儿童，成年，早期，晚期和成年后），白血球，粒细胞和淋巴细胞计数。结果一个包括所有四个生命阶段的SEP的模型都能最好地说明男女一生中SEP与白血球和粒细胞计数之间的关系，其中成年早期SEP（教育）贡献最大。关键时期模型最好地解释了生命过程SEP与淋巴细胞计数的关联以及性别特异性的关联。早期成人SEP与女性淋巴细胞负相关。结论终生SEP较低可能会对成年晚期免疫炎症状态产生负面影响。但是，免疫炎性状态的某些方面可能对早期暴露敏感，并且具有性别特异性关联。这些发现与以下假设相吻合：在不断发展的人口中，随着经济发展，促性腺轴的上调可能掩盖了社会优势通常对男性的保护作用。

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