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首页> 外文期刊>Psychoneuroendocrinology: An International Journal >Life long endogenous estrogen exposure and later adulthood cognitive function in a population of naturally postmenopausal women from Southern China: the Guangzhou Biobank Cohort Study.
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Life long endogenous estrogen exposure and later adulthood cognitive function in a population of naturally postmenopausal women from Southern China: the Guangzhou Biobank Cohort Study.

机译：来自中国南方的自然绝经后妇女群体的终身内源性雌激素暴露和成年后期的认知功能：广州生物银行队列研究。

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BACKGROUND: Estrogen has neurotrophic and neuroprotective properties in animal and in vitro studies. Epidemiological studies are inconclusive, but suggest a positive association between endogenous estrogen exposure (measured by reproductive period, the number of years between menarche and menopause) and later life cognitive function. METHODS: Structural equation modeling was used in a cross-sectional study of 11,094 naturally postmenopausal multiparous Chinese older (>/=50 years) women from the Guangzhou Biobank Cohort Study (phases 2 and 3) to assess the interrelationship of four proxies of higher endogenous estrogen exposure (longer reproductive period, older age of first pregnancy, lower parity and shorter average duration of breast feeding per child) with immediate and the delayed 10-word recall score in phases 2 and 3, and with the mini-mental state examination (MMSE) score in phase 3 (5641 women). RESULTS: Adjusted for age, education, childhood and adulthood socio-economic position and physical activity, longer reproductive period was associated with higher scores (0.02 words per year, 95% confidence interval (CI) 0.008-0.02 for delayed recall and 0.05 MMSE score, 95%CI 0.04-0.07, respectively). Lower parity and shorter average duration of breast-feeding per child were also associated with better cognitive function. CONCLUSIONS: In a large cohort of naturally postmenopausal Chinese women proxies of greater endogenous estrogen exposure were associated with better cognitive function. These findings support biological evidence for a cognitively protective role of endogenous estrogen.
机译：背景：雌激素在动物和体外研究中具有神经营养和神经保护特性。流行病学研究尚无定论，但表明内源性雌激素暴露（通过生殖期，初潮和绝经之间的年数来衡量）与以后的生活认知功能之间存在正相关。方法：采用结构方程模型对广州生物银行队列研究（第2和第3阶段）的11094名绝经后自然多产中国年龄较大（> / = 50岁）妇女进行横断面研究，以评估四种内源性较高的代理的相互关系在第2和第3阶段即刻和延迟的10字回想得分以及迷你智力状态检查（较长的生育期，第一次怀孕的年龄，较低的胎次和每个孩子的平均母乳喂养时间较短）下的雌激素暴露水平（ MMSE）得分在第三阶段（5641名女性）。结果：根据年龄，教育程度，童年和成年时期的社会经济地位和体育活动进行了调整，较长的生育期与较高的分数相关（每年0.02字，95％置信区间（CI）延迟回忆和0.00 MMSE分数为0.008-0.02 ，分别为95％CI 0.04-0.07）。较低的胎次和每个孩子的平均母乳喂养时间也与更好的认知功能有关。结论：在绝经后自然人群中，中国女性的大量内源性雌激素暴露水平与更好的认知功能有关。这些发现为内源性雌激素的认知保护作用提供了生物学证据。

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