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首页> 外文期刊>British Journal of Cancer >The natural history of metastasis of a syngeneic murine squamous carcinoma and the prognostic implications of primary tumour size and duration of growth
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The natural history of metastasis of a syngeneic murine squamous carcinoma and the prognostic implications of primary tumour size and duration of growth

机译：同源小鼠鳞状细胞癌的自然转移史以及原发肿瘤大小和生长持续时间的预后意义

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摘要

A study has been made of the natural history of metastasis of a spontaneous murine squamous carcinoma implanted into syngeneic recipients--a situation where biologically different tumours and variable "host resistance" are not complicating issues. The time distrubution of deaths from metastatic disease was incompatible with a log-normal distribution but was accurately described by an exponential pattern of survival following an initial lag. While the average life of doomed mice correlated with predictions based on growth rates, there was a wide range of survival times indicating random influences on the evolution of metastitic disease. Insofar as tumours which grew to 20 mm3 or less in 5 days after tumour cell injection failed to initiate metastases, while tumours which reached a size of 120 mm3 or greater (irrespective of duration) produced metastases in 38/39 mice, tumour size was a prognostic index. However, within the size range 33-150 mm3 the correlation between metastatic risk and size was not statistically significant. No correlation between metastatic risk and duration of tumour growth from 6 to 29 days was observed. Two integral functions of tumour size and duration were tested but neither gave a better correlation with metastatic risk than did size alone.
机译：已经对植入到同种受体中的自发鼠鳞状癌的转移的自然历史进行了研究，这种情况是生物学上不同的肿瘤和可变的“宿主抗性”不会使问题复杂化。转移性疾病死亡的时间分布与对数正态分布不符，但可以通过初始滞后后的生存指数规律准确描述。尽管注定死亡的小鼠的平均寿命与基于生长速率的预测相关，但存活时间范围很广，表明对转移性疾病的发展具有随机影响。就在注射肿瘤细胞后5天内生长到20 mm3或更小的肿瘤未能引发转移的范围，而大小达到120 mm3或更大（无论持续时间长短）的肿瘤在38/39小鼠中产生了转移，则肿瘤大小为预后指标。但是，在33-150 mm3的大小范围内，转移风险和大小之间的相关性在统计学上不显着。在6到29天的转移风险和肿瘤生长持续时间之间没有相关性。测试了两个肿瘤大小和持续时间的整体功能，但没有一个比单独的大小更好地与转移风险相关。

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