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首页> 外文期刊>British Journal of Cancer >Effect of inhaled plutonium dioxide on development of urethane-induced pulmonary adenomas
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Effect of inhaled plutonium dioxide on development of urethane-induced pulmonary adenomas

机译：吸入二氧化lu对尿烷诱发的肺腺瘤发展的影响

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Mice were exposed to plutonium dioxide (PuO2) aerosols 2 weeks before or after urethan injection. Both exposures reduced the number and size of adenomas. The incidence of arrested metaphases showed no consistently significant differences between plutonium-exposed and mock-exposed animals. The results are discussed in relation to recent electron microscopic evidence of degenerative changes in the type II epithelial cells of the mouse lung following PuO2 inhalation. It is concluded that damage at the cellular level may account for the observed reduction in growth of pulmonary adenomas in mice whose lungs contained plutonium particles.
机译：在注入尿烷之前或之后2周，​​将小鼠暴露于二氧化dioxide（PuO2）气溶胶中。两次暴露均减少了腺瘤的数量和大小。被捕中期的发生率显示，animals暴露和模拟暴露的动物之间没有一致的显着差异。结合最近的电子显微镜证据讨论了吸入PuO2后小鼠肺的II型上皮细胞的退行性变化的结果。结论是，在细胞水平上的损伤可能解释了在肺中含有contained颗粒的小鼠中观察到的肺腺瘤生长减少。

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