...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Journal of Cancer >Radioimmunotherapy of human hepatocellular carcinoma xenografts with 131I-labelled antiferritin antibody
【24h】

Radioimmunotherapy of human hepatocellular carcinoma xenografts with 131I-labelled antiferritin antibody

机译：131I标记的抗铁蛋白抗体对人肝癌异种移植物的放射免疫治疗

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of 131-labelled antiferritin polyclonal antibody for the treatment of established hepatocellular carcinoma (HC-04) in athymic nude mice were evaluated. 131I-labelled antiferritin antibody localised specifically to a subcutaneous tumour with a mean of 8.1% of the infused dose per gram of tumour at 24 h after infusion when the experiment was started 15 days after inoculation and with a mean of about 6.5% of the infused dose per gram of tumour when the experiment was started 30 days after tumour transplantation. The concentrations of 131I-antiferritin antibody in tumour delivered a mean of 1994 cGy to tumour following infusion of 500 microCi of radiolabelled antiferritin antibody in the early group and a mean of 1600 cGy in the late group. Treatment with 500 microCi led to regression of the tumour in 55% of animals in the early group and 44% in the late group. In contrast, unlabelled antiferritin and 131I-labelled IgG failed to exert any significant effect on tumour growth. The transplanted tumours in the early groups of animals had relatively higher concentration of ferritin than those in the late group. There was accelerated inhibition of tumour growth and prolonged survival in animals in the early group compared with those in the late group.
机译：评估了131标记的抗铁蛋白多克隆抗体对无胸腺裸鼠已建立的肝细胞癌（HC-04）的治疗作用。 131I标记的抗铁蛋白抗体特异地定位于皮下肿瘤，在接种后15天开始实验时，在注入后24小时，平均每克肿瘤的注入剂量为每克肿瘤注入剂量的8.1％，平均注入剂量的6.5％肿瘤移植后30天开始实验时，每克肿瘤的最大剂量。在早期组输注了500 microCi放射性标记的抗铁蛋白抗体后，肿瘤中131I-抗雌激素抗体的浓度将平均1994 cGy传递给肿瘤，晚期组则平均1600 cGy。用500 microCi进行治疗可导致早期组55％的动物肿瘤消退，晚期组44％的动物消退肿瘤。相反，未标记的抗铁蛋白和131I标记的IgG不能对肿瘤生长产生任何显着影响。动物早期组中的移植肿瘤中铁蛋白的浓度比晚期组中的相对高。与晚期组相比，早期组的动物对肿瘤生长的抑制作用得到了加速，并延长了存活期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号