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首页> 外文期刊>British Journal of Cancer >Some EPR Signals in Tumour Tissue
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Some EPR Signals in Tumour Tissue

机译：肿瘤组织中的一些EPR信号

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Normal and tumour tissues from rats, blood from normal and tumour bearing rats, and normal human blood were examined using the electron paramagnetic resonance (epr) technique. At low temperature a triplet epr signal, which is known to be produced by a NO-haemoprotein complex, was detected in some tumour samples and in decaying normal liver. At room temperature all of the tumour samples examined gave a doublet signal. This signal was also detected in blood but not in other normal tissues. The signal has a g value of 2·0054 ± 0·0002 and a hyperfine splitting of 1·80 ± 0·05 G and is assigned to the ascorbyl free radical. Model experiments suggest that the appearance of detectable concentrations of this radical result from a disturbance of the normal state of the ascorbic acid, dehydroascorbic acid redox system. It was verified that cell division is not responsible for the ascorbyl radical although autolysis may be involved. A possible relationship between the formation of ascorbyl radicals and other paramagnetic species in tumours is discussed.
机译：使用电子顺磁共振（epr）技术检查了大鼠的正常和肿瘤组织，正常和荷瘤大鼠的血液以及正常人的血液。在低温下，在一些肿瘤样品和正常肝衰变中检测到三重态的epr信号，已知是由NO-血红蛋白复合物产生的。在室温下，所有检查的肿瘤样品均发出双重信号。在血液中也检测到该信号，但在其他正常组织中未检测到。该信号的g值为2·0054±0·0002，超精细分裂为1·80±0·05 G，并分配给抗坏血酸自由基。模型实验表明，可检测浓度的该自由基的出现是由于抗坏血酸，脱氢抗坏血酸氧化还原系统的正常状态受到干扰。已证实，尽管可能涉及自溶，但细胞分裂并不负责抗坏血酸基团。讨论了肿瘤中抗坏血酸基的形成与其他顺磁性物质之间的可能关系。

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