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首页> 外文期刊>British Journal of Cancer >Early and late morphological changes (including carcinoma of the urothelium) induced by irradiation of the rat urinary bladder
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Early and late morphological changes (including carcinoma of the urothelium) induced by irradiation of the rat urinary bladder

机译：大鼠膀胱照射引起的早期和晚期形态变化（包括尿路上皮癌）

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Effects of X-irradiating the urinary bladder of female F344 rats with a single dose of 20 Gy were studied by light and electron microscopy. The animals were killed 1 week-20 months post-irradiation, and all tissues of the bladder wall were found to be affected by the irradiation. In the urothelium, damage was initially restricted to the basal cells but slowly extended to intermediate cells, and by 6 months post-irradiation the urothelium was focally hyperplastic. Twenty months post-irradiation, transitional-cell carcinomas were found in 10 of the surviving 17 animals (59%). The blood vessels in the bladder wall showed damage to both the endothelial cells and the smooth muscle. The fibroblasts in the connective tissue of the bladder wall appeared to show increased secretion after irradiation, and there was abundant collagen deposition, resulting in severe fibrosis of the bladder wall. After a latent period of a few months, focal degeneration and extensive necrosis of the smooth muscle cells were seen, leading to severe destruction and disorganization of the muscular coats of the bladder wall. Thus, a single dose of irradiation of 20 Gy was sufficient to produce severe fibrosis of the bladder wall with smooth muscle degeneration and to induce carcinoma of the urothelium in most of the treated animals within 20 months.
机译：用光和电子显微镜研究了单剂量20 Gy的X射线照射雌性F344大鼠的膀胱的效果。辐照后1周至20个月将动物处死，并发现辐照会影响膀胱壁的所有组织。在尿路上皮中，损伤最初仅限于基底细胞，但缓慢扩展到中间细胞，并且在照射后6个月，尿路上皮局部增生。辐射后二十个月，在幸存的17只动物中的10只（59％）中发现了移行细胞癌。膀胱壁的血管显示出内皮细胞和平滑肌的损伤。照射后，膀胱壁结缔组织中的成纤维细胞显示分泌增加，并且胶原蛋白沉积丰富，导致膀胱壁严重纤维化。在几个月的潜伏期后，可见平滑肌细胞的局灶性变性和广泛坏死，导致膀胱壁肌层的严重破坏和混乱。因此，20 Gy的单次照射足以在20个月内对大多数治疗的动物产生严重的平滑肌变性并引起膀胱壁严重纤维化，并诱发尿路上皮癌。

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