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首页> 外文期刊>British Journal of Cancer >Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance
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Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance

机译：肺癌患者严重的维生素C缺乏症：维生素C在手术修复中的应用以及与淋巴细胞相关的宿主抵抗

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Plasma and buffy-coat vitamin C were estimated in 158 samples from 139 lung-cancer patients, at all stages of the disease. Most samples showed hypovitaminosis C in both estimations: 64% had plasma, and 25% buffy-coat values below the thresholds for incipient clinical scurvy (0.3 mg% and 10 micrograms/10(8) cells respectively). Levels were diet-dependent and could be increased by oral supplements. Levels were low both in tumour-bearing patients and in those clinically free of disease after resection. The latter had particularly low values during the first 6 months, indicating the utilization of vitamin C in surgical repair. The vitamin C content of 13 primary lung tumours was assayed: tumours had a higher vitamin C content (mean 111.6 +/- 55.1 micrograms/g tissue) than normal lung (58.5 +/- 20.4 micrograms/g). Mononuclear cells from normal individuals show a higher vitamin C content than polymorphs, but in lung-cancer patients the expected correlation of buffy-coat vitamin C with the proportion of lymphocytes in peripheral blood was obscured by an inverse correlation in patients with relative lymphocytosis (greater than or equal to 25% lymphocytes), confirmed by an inverse correlation of the proportion of lymphocytes in peripheral blood with mononuclear-cell vitamin C in 14 patients in whom this was measured. These correlations were unaffected by controlling for plasma values, and indicate the utilization of vitamin C in lymphocyte-related anti-tumour mechanisms. Vitamin C is necessary for phagocytosis and for the expression of cell-mediated immunity. In view of the increasing circumstantial evidence that immune mechanisms exert some measure of control on tumour extension and metastasis in man, the effect of supplementation with vitamin C in lung-cancer patients on survival should be tested in a clinical trial.
机译：在疾病的所有阶段，从139名肺癌患者的158个样本中估计了血浆和血沉棕黄层维生素C。在这两种估计中，大多数样品均显示维生素C缺乏症：64％的血浆血浆和25％的血沉棕黄层值低于初始临床坏血病阈值（分别为0.3 mg％和10微克/ 10（8）细胞）。水平是饮食依赖性的，可以通过口服补充剂来增加。无论是肿瘤携带者还是切除后临床上没有疾病的患者，其水平都很低。后者在最初的6个月中的值特别低，表明在手术修复中维生素C的利用。测定了13种原发性肺肿瘤的维生素C含量：肿瘤的维生素C含量（平均111.6 +/- 55.1微克/克组织）比正常肺（58.5 +/- 20.4微克/克）更高。正常个体的单核细胞显示的维生素C含量高于多晶型物，但是在肺癌患者中，血沉棕黄层维生素C与外周血淋巴细胞比例的预期相关性被相对淋巴细胞增多的患者的逆相关性所掩盖（更大）小于或等于25％的淋巴细胞），通过测量14位患者外周血中淋巴细胞与单核细胞维生素C的比例成反比来证实。这些相关性不受血浆值控制的影响，表明维生素C在淋巴细胞相关的抗肿瘤机制中的利用。维生素C对于吞噬作用和细胞介导的免疫表达是必需的。鉴于越来越多的证据表明免疫机制对人的肿瘤扩展和转移具有一定的控制作用，因此应在临床试验中测试补充维生素C对肺癌患者生存的影响。

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