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Biological effects of tremolite

机译：透闪石的生物效应

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Tremolite is an amphibole which has been implicated in a variety of disease patterns in different parts of the world. It occurs in a number of phases, which are chemically identical but have specific physical characteristics. In an attempt to clarify the epidemiological findings, tremolite fibres of 3 specific forms--A, B and C--were characterized and studied for biological activity by: (i) in vivo intrapleural injection of rats (2 separate experiments--1 with poor survival). (ii) in vitro enzyme release from mouse peritoneal macrophages (iii) in vitro giant-cell formation in A549 cultures (iv) in vitro cytotoxicity for V79-4 cells. Sample C, which contained more long thin fibres than A and B, was alone in producing mesotheliomas. C, but not A or B, induced LDH and B-glucuronidase enzyme release, and induced giant cells. A was not cytotoxic, B moderately cytotoxic and C as highly cytotoxic as UICC crocidolite. The in vivo studies were marred by being split between 2 experiments, of which the second had poor survival. We are aware of the weakness of our in vivo data, but as Tremolite C was being considered for commercial use on the European market we felt it timely to submit our findings for publication.
机译：透闪石是一种闪石，已与世界不同地区的多种疾病有关。它以化学上相同但具有特定物理特性的多个阶段发生。为了阐明流行病学发现，通过以下方法对3种特定形式的透闪石纤维（A，B和C）进行了表征和生物学活性研究：（i）体内胸膜内注射大鼠（2个独立实验，-1生存能力差）。 （ii）小鼠腹膜巨噬细胞的体外酶释放（iii）A549培养物中的体外巨细胞形成（iv）V79-4细胞的体外细胞毒性。包含比A和B长得多的细纤维的样品C单独用于产生间皮瘤。 C而不是A或B诱导LDH和B-葡糖醛酸糖苷酶释放，并诱导巨细胞。 A没有细胞毒性，B具有中等细胞毒性，C与UICC青石棉一样具有高度细胞毒性。体内研究被分为两个实验而受到损害，其中第二个实验的生存期较差。我们知道体内数据的弱点，但是由于Tremolite C被考虑在欧洲市场上进行商业使用，因此我们认为将我们的发现提交出版物的时机已经到了。

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