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首页> 外文期刊>British Journal of Cancer >The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma
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The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma

机译：肿瘤负荷和治疗对眼和皮肤黑素瘤患者细胞毒性反应的影响

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Using a microassay for cellular immunity, tumour specific cytotoxicity was detected in 2/5 cases of ocular melanoma and 1/3 cases of primary cutaneous melanoma before treatment. Reactivity was measured against allogeneic skin melanoma target cells in short or long term in vitro culture. Lymphoid cells from patients with disseminated cutaneous melanoma were either non-reactive (4/8 cases) or gave a nonspecific cytotoxicity on target cells of diverse histogenic origins. Among tumour-free patients tested after surgery, 0/2 patients with ocular tumour were non-reactive 3-4 months post surgery. After sugical excision of cutaneous melanoma 2/2 patients gave tumour specific reactions during the first month after surgery. After longer time intervals, from 5 months to 3 years, only 1/8 patients were reactive. Preoperative radiotherapy in a total skin dose of 10,000 rad produ-ed a transient tumour specific reaction 24 h after therapy in a single case. Following local tumour excision in patients given preoperative irradiation, 2 cases which had previously demonstrated tumour specific CMI lost reactivity. Among 14 tumour-free individuals tested only after preoperative radiotherapy and surgery, at intervals from 5 day to 13 years, a single case gave tumour specific CMI. Palliative irradiation in doses 4000-4960 rad to the inguinal or axillary lymph nodes was found to induce a generalized lymphopenia within 48 h after treatment. Lymphoid cell preparations from patients with localized melanoma contained significantly increased numbers of immature cells (lymphoblasts and myeloblasts) and myeloid precursor elements. Those prepared from patients with disseminated disease had in addition elevated levels of eosinophils but reduced numbers of recoverable lymphocytes.
机译：使用用于细胞免疫的微量测定法，在治疗前，在2/5例眼部黑色素瘤和1/3例原发性皮肤黑素瘤中检测到了肿瘤特异性细胞毒性。在短期或长期体外培养中针对同种异体皮肤黑色素瘤靶细胞测量了反应性。弥漫性皮肤黑色素瘤患者的淋巴样细胞无反应（4/8例）或对多种组织起源的靶细胞具有非特异性的细胞毒性。在接受手术治疗的无肿瘤患者中，有0/2的眼部肿瘤患者术后3-4个月无反应。手术切除皮肤黑色素瘤后，有2/2名患者在手术后的第一个月出现了肿瘤特异性反应。从5个月到3年的较长时间间隔后，只有1/8例患者有反应。在单个病例中，治疗后24小时，皮肤总剂量为10,000 rad的术前放疗产生了短暂的肿瘤特异性反应。在接受术前放疗的患者中局部切除肿瘤后，有2例先前证明肿瘤特异性CMI丧失了反应性。仅在术前放疗和手术后接受测试的14位无肿瘤个体中，间隔5天至13年，其中一例给予了肿瘤特异性CMI。发现腹股沟或腋窝淋巴结的剂量为4000-4960 rad的姑息照射在治疗后48小时内可诱发全身性淋巴细胞减少。来自局部黑色素瘤患者的淋巴样细胞制剂中未成熟细胞（淋巴母细胞和成肌细胞）和髓样前体元素的数量显着增加。从散播疾病患者中制备的那些患者嗜酸性粒细胞水平升高，但可恢复淋巴细胞数量减少。

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