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首页> 外文期刊>British Journal of Cancer >Flavonoid intake and breast cancer risk: a case|[ndash]|control study in Greece
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Flavonoid intake and breast cancer risk: a case|[ndash]|control study in Greece

机译：类黄酮摄入与乳腺癌风险：希腊的病例| ndash |对照研究

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Flavonoids have been investigated for possible inverse associations with various chronic degenerative diseases, but there are no epidemiologic data concerning a possible association between several of the main flavonoid categories and breast cancer risk. We have applied recently published data on the flavonoid content of several foods and beverages on dietary information collected in the context of a large case–control study of 820 women with breast cancer and 1548 control women, conducted in Greece. We found a strong, statistically significant inverse association of flavone intake with breast cancer. The odds ratio for an increment equal to one standard deviation of daily flavone intake (i.e. 0.5?mg?day?1) was 0.87, with 95% confidence interval 0.77–0.97. The association persisted after controlling for fruit and vegetable consumption, or for other flavonoid intake. This inverse association is compatible with and may explain the reported inverse association of breast cancer with consumption of vegetables, particularly leafy vegetables. After controlling for dietary confounding, there was no association of breast cancer risk with flavanones, flavan-3-ols, flavonols, anthocyanidins or isoflavones.
机译：已经研究了类黄酮与各种慢性退行性疾病的可能逆相关性，但是尚无流行病学数据，涉及几种主要类黄酮与乳腺癌风险之间的可能相关性。在希腊进行的一项针对820名乳腺癌妇女和1548名对照妇女的大型病例对照研究中，我们从饮食信息中收集了一些食品和饮料中类黄酮含量的最新公布数据。我们发现黄酮摄入与乳腺癌之间存在强烈的，统计学意义上的显着负相关。等于每日黄酮摄入量一个标准偏差（即0.5？mg？day？1）的比值比为0.87，95％置信区间为0.77-0.97。在控制了水果和蔬菜的摄入量或其他类黄酮的摄入量之后，这种联系持续存在。这种反向关联与食用蔬菜，特别是多叶蔬菜的乳腺癌的报道的反向关联是相容的，并且可以解释乳腺癌的反向关联。在控制饮食混杂因素后，黄烷酮，黄烷-3-醇，黄酮醇，花青素或异黄酮与乳腺癌风险无关。

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