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首页> 外文期刊>British Journal of Cancer >Earlier surveillance colonoscopy programme improves survival in patients with ulcerative colitis associated colorectal cancer: results of a 23-year surveillance programme in the Japanese population
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Earlier surveillance colonoscopy programme improves survival in patients with ulcerative colitis associated colorectal cancer: results of a 23-year surveillance programme in the Japanese population

机译：早期的结肠镜检查计划可改善溃疡性结肠炎相关大肠癌患者的生存：日本人群实施23年监测计划的结果

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摘要

Patients with long-standing ulcerative colitis (UC) are known to have an increased risk for the development of colorectal cancer (CRC). The aim of this study was to clarify the cumulative risk for the development of dysplasia or invasive cancer and the effectiveness of surveillance colonoscopy in the Japanese population. A total of 217 patients received a total of 1027 surveillance colonoscopies between January 1979 and December 2001 at the University of Tokyo hospital. Patients with invasive cancer found in the surveillance group were compared to those referred to our hospital from the other hospitals without surveillance colonoscopy. Surveillance colonoscopy confirmed 15 patients with definite dysplasia. Of these, five were proved to have invasive cancer in the resected specimens. The cumulative risk for the development of invasive cancer at 10, 20, and 30 years was 0.5, 4.1, and 6.1%, respectively, while that for the development of definite dysplasia at 10, 20, and 30 years was 3.1, 10.0, and 15.6%, respectively. All the patients with invasive cancer in the surveillance group remained alive, while three out of four patients in the nonsurveillance group died. Our surveillance programme is useful for detecting UC-associated CRC, and survival may be improved by surveillance colonoscopy.
机译：患有长期溃疡性结肠炎（UC）的患者患结直肠癌（CRC）的风险增加。这项研究的目的是弄清日本人群中发育异常或浸润性癌发展的累积风险以及监测结肠镜检查的有效性。在1979年1月至2001年12月之间，共有217例患者在东京大学医院接受了共1027例结肠镜检查。将在监视组中发现的浸润性癌症患者与没有进行结肠镜检查的其他医院转诊到我们医院的患者进行比较。结肠镜检查证实15例明确发育异常。其中，有五个被证明在切除的标本中具有浸润性癌症。在10、20和30岁时发生浸润癌的累积风险分别为0.5％，4.1和6.1％，而在10、20和30岁时发生一定发育异常的累积风险分别为3.1、10.0和分别为15.6％。监视组中所有浸润性癌症患者均存活，而非监视组中四分之三的患者死亡。我们的监测程序可用于检测UC相关的CRC，并且通过监测结肠镜检查可提高生存率。

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