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首页> 外文期刊>British Journal of Cancer >Peripheral plasma immunoreactive 6-oxo-postaglandin F1 α and gynaecological tumours
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Peripheral plasma immunoreactive 6-oxo-postaglandin F1 α and gynaecological tumours

机译：外周血浆免疫反应性6-氧-postaglandin F1α与妇科肿瘤

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摘要

Peripheral plasma levels of immunoreactive 6-oxo-PGF1 alpha, the stable hydrolysis product of prostacyclin, were significantly higher in female patients with tumours of the genital tract than in normal controls. In the groups with malignant tumours, these high levels declined after operation and/or radiotherapy if the tumour responded to treatment. In patients who did not respond to treatment or with tumour recurrence, levels of plasma 6-oxo-PGF1 alpha remained high or even rose further. Benign gynaecological tumours were also associated with significantly raised plasma 6-oxo-PGF1 alpha levels, and these fell to normal levels immediately on surgical removal of the tumour. Possible reasons for these alterations are described. Further investigations are warranted to see whether serial measurements of plasma 6-oxo-PGF1 alpha could be used as a prognostic index for the clinical status of patients with gynaecological tumours.
机译：具有生殖道肿瘤的女性患者的免疫反应性6-氧代-PGF1α（前列环素的稳定水解产物）的外周血浆水平显着高于正常对照组。在恶性肿瘤组中，如果肿瘤对治疗有反应，这些高水平在手术和/或放疗后下降。在对治疗无反应或肿瘤复发的患者中，血浆6-氧代-PGF1α的水平仍然很高，甚至进一步升高。良性妇科肿瘤还与血浆6-氧代-PGF1α水平显着升高有关，并且在手术切除肿瘤后立即降至正常水平。描述了这些更改的可能原因。有必要进行进一步的研究，以查看是否可以将血浆6-氧代-PGF1α的系列测量结果作为妇科肿瘤患者临床状况的预后指标。

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