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首页> 外文期刊>British Journal of Cancer >Atrophic gastritis and vitamin C status in two towns with different stomach cancer death-rates
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Atrophic gastritis and vitamin C status in two towns with different stomach cancer death-rates

机译：胃癌死亡率不同的两个城镇的萎缩性胃炎和维生素C状况

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A survey was conducted of 513 men aged 65 74 years living in two British towns with high and low stomach cancer death-rates. The prevalence of severe atrophic gastritis (defined as a serum pepsinogen I less than 20 micrograms l-1) was significantly higher in the high-risk than in the low-risk town (14.5% and 7.7% respectively); it also tended to be higher in the manual workers, who are known to have a greater risk of stomach cancer than non-manual workers. The manual workers in the high-risk town were particularly likely to have had a partial gastrectomy. Plasma ascorbate concentration and fruit intake were lower in the high-risk area and lower social classes, suggesting a poorer vitamin C status. There was, however, no direct relationship between ascorbate concentration and the presence of severe atrophic gastritis. These findings are consistent with the hypothesis that risk of stomach cancer is determined in two stages--a long-term effect, producing atrophic gastritis; and a short-term effect in which vitamin C is protective.
机译：对居住在英国两个城镇中胃癌死亡率高低的513名65岁74岁的男性进行了调查。重度萎缩性胃炎（定义为血清胃蛋白酶原I低于20微克l-1）的发生率在高危人群中明显高于低危人群（分别为14.5％和7.7％）;体力劳动者的胃癌发病率也往往更高，据了解，体力劳动者比非体力劳动者患胃癌的风险更大。高危小镇的体力劳动者尤其有可能进行了部分胃切除术。在高风险地区和较低的社会阶层中血浆抗坏血酸浓度和水果摄入量较低，表明维生素C状况较差。然而，抗坏血酸浓度与严重萎缩性胃炎的存在没有直接关系。这些发现与以下假设相吻合：胃癌的风险是在两个阶段中确定的-长期作用会产生萎缩性胃炎;以及维生素C具有保护作用的短期作用。

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