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首页> 外文期刊>British Journal of Cancer >Radiation-induced myeloid leukaemia in CBA/H mice: A non-immunogenic malignant disease in syngeneic mice
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Radiation-induced myeloid leukaemia in CBA/H mice: A non-immunogenic malignant disease in syngeneic mice

机译：辐射诱发的CBA / H小鼠骨髓性白血病：同基因小鼠的非免疫原性恶性疾病

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摘要

in vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immunization with radiation-inactivated cells or by sublethal whole-body irradiation of recipients before inoculation of small numbers of clonogenic cells. Since the growth stimuli involved in in vivo repair of severely damaged normal haemopoietic tissue also did not modify the growth of the radiation-induced leukaemia cells in syngeneic passage, their growth in vivo in the irradiated primary hosts can be regarded as autonomous by the stage at which leukaemia was diagnosed. Challenge inocula in the "immunization" experiments were 1-9 clonogenic cells from 4 different passaged lines and in the whole-body radiation experiments, 1-10(3) clonogenic cells derived from 11 different primary hosts and 4 different passaged lines.
机译：通过CBA / H雄性小鼠的全身照射诱导的髓样白血病的体内生长特征通过预期可增强或抑制免疫学反应的方法在起源菌株中进行了检查。尝试通过用辐射灭活的细胞进行主动免疫或在接种少量克隆细胞之前先对受体进行亚致死性全身照射，不能改变体内的同基因生长（存活时间和服用频率）。由于参与严重受损的正常造血组织的体内修复的生长刺激也未通过同基因传代改变辐射诱导的白血病细胞的生长，因此在以下阶段可以认为它们在辐射的主要宿主体内的生长是自主的被诊断出白血病。 “免疫”实验中的挑战接种物是来自4种不同传代细胞系的1-9个克隆形成细胞，而在全身放射实验中，来自11种不同主要宿主和4种不同传代细胞系的1-10（3）克隆形成细胞。

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