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首页> 外文期刊>British Journal of Cancer >Placental-type alkaline phosphatase in cervical neoplasia
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Placental-type alkaline phosphatase in cervical neoplasia

机译：胎盘型碱性磷酸酶在宫颈癌中的作用

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摘要

Monoclonal antibodies reactive with placental-type alkaline phosphatase have formed the basis of methods for detection of this oncodevelopmental antigen in patients with pre-invasive and invasive cervical neoplasia, with or without evidence of papilloma virus infection. Disease-related elevations of placental-type alkaline phosphatase were not observed in patients' sera. Solubilised cervical smears or biopsy material, and cervical mucus swabs, often contained substantial amounts of this isoenzyme; however, there was no significant difference between any of the patient and control groups. Thus, serological and smear test assays for placental-type alkaline phosphatase were not useful in differential diagnosis of cervical lesions. However, its presence in most biopsy specimens, often at high levels, indicated possible application for in vivo radioimmunoimaging studies of invasive or metastatic cervical cancer.
机译：可与胎盘型碱性磷酸酶反应的单克隆抗体已成为检测有或无乳头状瘤病毒感染迹象的浸润前和浸润性宫颈癌患者中这种癌中发展抗原的方法的基础。在患者血清中未观察到与疾病相关的胎盘型碱性磷酸酶升高。溶解的宫颈涂片或活检材料以及宫颈粘液拭子通常含有大量的这种同工酶。但是，任何患者和对照组之间都没有显着差异。因此，胎盘型碱性磷酸酶的血清学检查和涂片检查不能用于宫颈病变的鉴别诊断。然而，它在大多数活检标本中的存在，通常是高水平的存在，表明可能用于浸润性或转移性宫颈癌的体内放射免疫成像研究。

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