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首页> 外文期刊>British Journal of Cancer >The 1987 Walter Hubert lecture: Regulation and deficiencies in DNA repair|[ast]|
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The 1987 Walter Hubert lecture: Regulation and deficiencies in DNA repair|[ast]|

机译：1987年的Walter Hubert演讲：DNA修复的规则和缺陷

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A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well characterised repair defects. This analogy provides leads for unravelling the molecular alterations in such cancer-prone human cells. The inducibility of DNA repair enzymes is also reviewed. Exposure of bacteria to alkylating agents, or oxygen radicals, causes the overproduction of several novel and interesting repair activities, and the induced bacteria provide an abundant source of these proteins for purification and biological characterisation. Enzymes with the same defined specificities are often present in human cells, presumably serving the same functions as in microorganisms, but these activities are only constitutively expressed at low levels.
机译：许多罕见的人类遗传综合征与DNA修复中的明显缺陷和癌症发生率大大增加有关。从这类个体衍生的细胞系在表型上类似于某些细菌突变株，这些菌株对辐射或化学试剂的敏感性增加并且特征明确的修复缺陷。这种类比为揭示这种易患癌症的人类细胞中的分子变化提供了线索。还对DNA修复酶的诱导性进行了综述。细菌暴露于烷基化剂或氧自由基会导致几种新颖而有趣的修复活性过度产生，并且诱导的细菌为纯化和生物学表征提供了这些蛋白质的丰富来源。具有相同定义特异性的酶通常存在于人细胞中，推测其功能与微生物相同，但这些活性仅以低水平组成性表达。

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