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首页> 外文期刊>British Journal of Cancer >Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites
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Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites

机译：生殖器癌症患者和五个不同生殖器外部位癌症患者血清中对人乳头瘤病毒16型L1病毒样颗粒的反应性

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A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the Slotervaart Hospital in Amsterdam, the Netherlands. Presence of HPV 16 specific antibody was assessed using HPV 16 L1 capsids. Sera positive for HPV 16 capsid antibody were further tested for antibody against HPV 16 E7 peptides. Prevalence of antibody against HPV 16 L1 capsids among both the negative control group without cancer and the negative control group with gastric cancer was 18%, while seroprevalence among the control group of patients with HPV-associated cervical squamous cell carcinoma was 47% (PPP=0.04) and among patients with oesophageal squamous cell carcinoma 14% (P=0.7). The serological evidence for association between HPV 16 infection and both oropharyngeal carcinoma and penile carcinoma was established. The conclusion that no association was found between the presence of antibody against HPV 16 L1 capsids and oesophageal squamous cell carcinoma was in accordance with results of other studies carried out in the Netherlands using HPV DNA technology. In the subjects with HPV 16 L1 capsid antibody, no association was found between the antibody against HPV 16 E7 and clinical outcome.
机译：进行了一项回顾性血清流行病学研究，以检查人乳头瘤病毒（HPV）16感染与口咽，食道，阴茎和阴道癌之间的关系。血清是从荷兰安东尼·范·吕温霍克医院（荷兰癌症研究所）和荷兰阿姆斯特丹的斯洛特瓦特医院的血清库中选择的。使用HPV 16 L1衣壳评估HPV 16特异性抗体的存在。对HPV 16衣壳抗体阳性的血清进一步测试抗HPV 16 E7肽的抗体。在没有癌症的阴性对照组和有胃癌的阴性对照组中，针对HPV 16 L1衣壳的抗体的患病率为18％，而与HPV相关的宫颈鳞状细胞癌的对照组的血清阳性率为47％（ PPP = 0.04）和食管鳞状细胞癌患者中14％（P = 0.7）。建立了HPV 16感染与口咽癌和阴茎癌之间相关性的血清学证据。在荷兰使用HPV DNA技术进行的其他研究的结果表明，针对HPV 16 L1衣壳的抗体与食道鳞状细胞癌之间没有关联的结论。在具有HPV 16 L1衣壳抗体的受试者中，针对HPV 16 E7的抗体与临床结果之间未发现关联。

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