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首页> 外文期刊>British Journal of Cancer >Differential CD44 expression patterns in primary brain tumours and brain metastases
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Differential CD44 expression patterns in primary brain tumours and brain metastases

机译：CD44在原发性脑肿瘤和脑转移瘤中的差异表达模式

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Splicing variants of CD44 (CD44v) are increasingly recognised as metastasis-promoting factors in rodent and some human cancers. However, the frequency for CD44v expression in human cancers and their metastases and the status of CD44v expression in low or non-metastatic tumours is still uncertain. To address this issue, we investigated CD44 expression patterns in brain metastases (BMTs) spread from more than ten organs and five types of primary brain tumours (PBTs) by Northern blot, reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemical analysis. The results demonstrated that all of the 56 PBTs examined express standard form of CD44 (CD44s) but none of them express CD44v. In contrast, 22 of 26 BMTs studied were found with CD44v expression. Our data thus present direct evidence of a general distribution of CD44 in BMTs but suggest that such expression is an extremely rare event in PBTs. Therefore, the presence or absence of CD44v expression may be related to high or low metastatic potential of human malignancies.
机译：CD44（CD44v）的剪接变体越来越被认为是啮齿动物和某些人类癌症中的转移促进因子。然而，在人类癌症及其转移中CD44v表达的频率以及在低或非转移性肿瘤中CD44v表达的状态仍然不确定。为了解决这个问题，我们通过Northern印迹，逆转录-聚合酶链反应（RT-PCR）和免疫细胞化学分析研究了从十多个器官和五种类型的原发性脑肿瘤（PBT）传播的脑转移（BMT）中的CD44表达模式。结果表明，所检查的所有56个PBT均表达标准形式的CD44（CD44s），但都不表达CD44v。相反，在研究的26个BMT中，有22个具有CD44v表达。因此，我们的数据提供了CD44在BMT中普遍分布的直接证据，但表明这种表达在PBT中是极为罕见的事件。因此，CD44v表达的存在与否可能与人类恶性肿瘤的高或低转移潜力有关。

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