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首页> 外文会议>Multiphoton microscopy in the biomedical sciences XVII >MULTIMODAL OPTICAL IMAGING DATABASE FROM TUMOUR BRAIN HUMAN TISSUE: ENDOGENEOUS FLUORESCENCE FROM GLIOMAS, METASTASES AND CONTROL TISSUES
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MULTIMODAL OPTICAL IMAGING DATABASE FROM TUMOUR BRAIN HUMAN TISSUE: ENDOGENEOUS FLUORESCENCE FROM GLIOMAS, METASTASES AND CONTROL TISSUES

机译：肿瘤脑组织的多模态光学成像数据库：来自胶质瘤，转移瘤和对照组织的内源性荧光

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摘要

Eliminating time-consuming process of conventional biopsy is a practical improvement, as well as increasing the accuracy of tissue diagnoses and patient comfort. We addressed these needs by developing a multimodal nonlinear endomicroscope that allows real-time optical biopsies during surgical procedure. It will provide immediate information for diagnostic use without removal of tissue and will assist the choice of the optimal surgical strategy. This instrument will combine several means of contrast: non-linear fluorescence, second harmonic generation signal,reflectance, fluorescence lifetime and spectral analysis. Multimodality is crucial for reliable and comprehensive analysis of tissue. Parallel to the instrumental development, we currently improve our understanding of the endogeneous fluorescence signal with the different modalities that will be implemented in the stated. This endeavor will allow to create a database on the optical signature of the diseased and control brain tissues. This proceeding will present the preliminary results of this database on three types of tissues: cortex, metastasis and glioblastoma.
机译：消除常规活检耗时的过程是一项实际的改进，同时也提高了组织诊断的准确性和患者的舒适度。我们通过开发一种多模式非线性内窥镜满足了这些需求，该显微镜可以在手术过程中进行实时光学活检。它将提供即时信息以用于诊断用途，而无需去除组织，并将协助选择最佳手术策略。该仪器将结合多种对比手段：非线性荧光，二次谐波产生信号，反射率，荧光寿命和光谱分析。多模式对于组织的可靠和全面分析至关重要。与仪器开发平行的是，我们目前正在以陈述中将要实现的不同方式改进对内源性荧光信号的理解。这项工作将允许创建有关患病和控制脑组织的光学特征的数据库。该过程将介绍该数据库在三种类型的组织上的初步结果：皮层，转移和胶质母细胞瘤。

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  • 会议地点 San Francisco(US)
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    Fanny Poulon; Ali Ibrahim; Marc Zanello; Johan Pallud; Pascale Varlet; Fatima Melouki; Georges Abi Lahoud; Bertrand Devaux; Darine Abi Haidar;

  • 作者单位

    IMNC Laboratory, UMR 8165-CNRS/ IN2P3, Paris-Saclay university, 91405 Orsay, France;

    IMNC Laboratory, UMR 8165-CNRS/ IN2P3, Paris-Saclay university, 91405 Orsay, France;

    Neurosurgery Department, Sainte-Anne Hospital, Paris, France;

    Neurosurgery Department, Sainte-Anne Hospital, Paris, France,Univ.Paris Descartes, Paris,France,IMABRAIN, INSERM U894;

    Univ.Paris Descartes, Paris,France,IMABRAIN, INSERM U894,Neuropathology Department,Sainte-Anne Hospital, France;

    IMNC Laboratory, UMR 8165-CNRS/ IN2P3, Paris-Saclay university, 91405 Orsay, France;

    Neurosurgery Department, Sainte-Anne Hospital, Paris, France,Univ.Paris Descartes, Paris,France;

    Neurosurgery Department, Sainte-Anne Hospital, Paris, France,Univ.Paris Descartes, Paris,France;

    IMNC Laboratory, UMR 8165-CNRS/ IN2P3, Paris-Saclay university, 91405 Orsay, France,Paris Diderot University, Sorbonne Paris Cité, F-75013, Paris, France;

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