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首页> 外文会议>Conference on multiphoton microscopy in the biomedical sciences XVII >MULTIMODAL OPTICAL IMAGING DATABASE FROM TUMOUR BRAIN HUMAN TISSUE: ENDOGENEOUS FLUORESCENCE FROM GLIOMAS, METASTASES AND CONTROL TISSUES
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MULTIMODAL OPTICAL IMAGING DATABASE FROM TUMOUR BRAIN HUMAN TISSUE: ENDOGENEOUS FLUORESCENCE FROM GLIOMAS, METASTASES AND CONTROL TISSUES

机译：来自肿瘤脑部人体组织的多模式光学成像数据库：来自胶质瘤，转移和对照组织的内核荧光

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Eliminating time-consuming process of conventional biopsy is a practical improvement, as well as increasing the accuracy of tissue diagnoses and patient comfort. We addressed these needs by developing a multimodal nonlinear endomicroscope that allows real-time optical biopsies during surgical procedure. It will provide immediate information for diagnostic use without removal of tissue and will assist the choice of the optimal surgical strategy. This instrument will combine several means of contrast: non-linear fluorescence, second harmonic generation signal,reflectance, fluorescence lifetime and spectral analysis. Multimodality is crucial for reliable and comprehensive analysis of tissue. Parallel to the instrumental development, we currently improve our understanding of the endogeneous fluorescence signal with the different modalities that will be implemented in the stated. This endeavor will allow to create a database on the optical signature of the diseased and control brain tissues. This proceeding will present the preliminary results of this database on three types of tissues: cortex, metastasis and glioblastoma.
机译：消除常规活检的耗时过程是一种实际改善，以及增加组织诊断和患者舒适度的准确性。我们通过开发多峰非线性计镜检查允许在手术过程中实时光学活检的多模式非线性计时器来解决这些需求。它将立即提供诊断使用的信息，而不会去除组织，并有助于选择最佳的外科策略。该仪器将结合多种对比度：非线性荧光，二次谐波产生信号，反射率，荧光寿命和光谱分析。多模是对组织可靠和综合分析至关重要。与仪器开发平行，我们目前提高了对具有不同模式的内核荧光信号的理解，该信号将在规定中实施。这一努力将允许在患病和控制脑组织的光学签名上创建数据库。此程序将在三种组织中提出该数据库的初步结果：皮质，转移和胶质母细胞瘤。

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