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首页> 外文期刊>British Journal of Cancer >Detection of Anti-tumour Cell Mediated Immunity and Serum Blocking Factors in Cancer Patients by the Leucocyte Adherence Inhibition Test
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Detection of Anti-tumour Cell Mediated Immunity and Serum Blocking Factors in Cancer Patients by the Leucocyte Adherence Inhibition Test

机译：白细胞粘附抑制试验检测癌症患者抗肿瘤细胞介导的免疫和血清阻断因子

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摘要

The leucocyte adherence inhibition (LAI) test, previously described for the detection of cell mediated immunity and serum blocking factors associated with murine tumours, has now been adapted for use with human cancer patients. Blood leucocytes from these patients, mixed in vitro with antigenic extracts of tumours of the same type, had their normal adherence to glass surfaces diminished. This inhibition was reversed (blocked) by the addition of the patients' own sera. Both LAI and blocking were tumour-type specific, but showed complete cross-reactivity within each type of tumour (melanoma, colon carcinoma, mammary carcinoma).The LAI test could be of great value in diagnosis and evaluation of treatment, since it seems to reproduce consistently the findings made by more elaborate techniques but has the advantage of being simple, rapid and inexpensive.
机译：先前描述用于检测与鼠肿瘤相关的细胞介导的免疫力和血清阻断因子的白细胞粘附抑制（LAI）测试现已适用于人类癌症患者。这些患者的血液白细胞在体外与相同类型肿瘤的抗原提取物混合后，对玻璃表面的正常粘附力降低。通过添加患者自己的血清可以逆转（阻断）这种抑制作用。 LAI和阻断均是肿瘤类型特异性的，但在每种类型的肿瘤（黑色素瘤，结肠癌，乳癌）中均显示出完全的交叉反应性。LAI测试可能对诊断和评估治疗具有重要价值。始终如一地再现由更精细的技术得出的结论，但具有简单，快速和廉价的优势。

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