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首页> 外文期刊>British Journal of Cancer >E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus
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E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus

机译：E-钙粘蛋白在原发性和转移性胸膜肿瘤以及巴雷特食管中的表达

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Reduced expression of E-cadherin, a Ca(2+)-dependent cell adhesion molecule present in normal epithelium, has been associated with invasive and metastatic cancer. Immunohistochemistry was used in examining the relationship between E-cadherin expression and stage in 59 oesophageal and 52 lung cancers. Advanced-stage oesophageal cancers were associated with both reduced and disorganised E-cadherin expression (P 0.05). No differences in stage were seen between tumours with reduced or disorganised E-cadherin expression. Altered E-cadherin expression was detected in dysplastic, non-invasive Barrett's oesophagus. Importantly, high-level E-cadherin expression was detected in 17 of 17 lymph nodes containing metastatic cancer. E-cadherin mRNA expression was decreased in tumours with reduced protein expression, but not in tumours with disorganised expression. Expression of alpha-catenin mRNA, an E-cadherin-associated protein, was detected in tissues with altered E-cadherin protein expression. Reduced and disorganised expression of E-cadherin appear to be related to transcriptional and post-translational events respectively, and both appear to represent altered cell adhesion associated with invasion and metastasis in thoracic neoplasms.
机译：E-钙粘着蛋白，一种存在于正常上皮中的Ca（2+）依赖性细胞粘附分子，其表达降低与侵袭性和转移性癌症有关。免疫组织化学用于检查59例食道癌和52例肺癌中E-钙黏着蛋白表达与分期之间的关系。晚期食管癌与E-钙黏着蛋白表达降低和紊乱有关（P 0.05）。在E-钙粘着蛋白表达降低或紊乱的肿瘤之间，未见分期差异。在发育不良的非侵入性Barrett食管中检测到E-钙粘蛋白表达改变。重要的是，在含有转移性癌症的17个淋巴结中有17个检测到高水平的E-钙粘蛋白表达。 E-cadherin mRNA表达在蛋白表达降低的肿瘤中降低，但在表达紊乱的肿瘤中未降低。在具有改变的E-钙粘蛋白蛋白表达的组织中检测到α-连环蛋白mRNA的表达，E-钙粘蛋白相关蛋白。 E-钙粘着蛋白的表达降低和紊乱似乎分别与转录和翻译后事件有关，并且都似乎代表与胸腔肿瘤的浸润和转移相关的细胞粘附改变。

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