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首页> 外文期刊>British Journal of Cancer >Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
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Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma

机译：碳酸酐酶XII是浸润性乳腺癌预后良好的标志

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Hypoxia and pH influence gene expression in tumours, and it is becoming increasingly clear that the pattern of genes expressed by a tumour determines its growth and survival characteristics. Hypoxia-inducible factor-1 (HIF-1) is a key mediator of the cellular response to hypoxia and high HIF-1 expression has been identified as a poor prognostic factor in tumours. Recently, we identified the tumour-associated carbonic anhydrases (CA), CA9 and CA12 as hypoxia-inducible in tumour cell lines. Furthermore, we identified CA IX to be a poor prognostic factor in breast cancer. The aim of this study was to assess the prognostic significance of CA XII. CA XII expression was studied by immunohistochemistry in a series of 103 cases of invasive breast cancer and any association with recognised prognostic factors or relation with the outcome was examined. CA XII expression was present in 77 out of 103 (75%) cases and was associated with lower grade (P=0.001), positive estrogen receptor status (PPPP=0.04) and a better overall survival (P=0.01). In conclusion, CA XII expression is influenced both by factors related to differentiation and hypoxia in breast cancer in vivo and CA XII expression is associated with a better prognosis in an unselected series of invasive breast carcinoma patients.
机译：缺氧和pH影响肿瘤中的基因表达，并且越来越清楚的是，肿瘤表达的基因模式决定了其生长和生存特征。缺氧诱导因子-1（HIF-1）是细胞对缺氧反应的关键介体，高HIF-1表达已被认为是肿瘤的不良预后因子。最近，我们确定肿瘤细胞系中与肿瘤相关的碳酸酐酶（CA），CA9和CA12为低氧诱导型。此外，我们确定CA IX是乳腺癌的不良预后因素。这项研究的目的是评估CA XII的预后意义。通过免疫组织化学在一系列103例浸润性乳腺癌中研究了CA XII的表达，并检查了与公认的预后因素或与预后的关系。在103例病例中，有77例（75％）出现了CA XII表达，与低级（P = 0.001），雌激素受体状态阳性（PPPP = 0.04）和更好的总体生存率（P = 0.01）相关。总之，CA XII的表达受体内分化和缺氧相关因素的影响，并且CA XII的表达与未选择的一系列浸润性乳腺癌患者的预后更好相关。

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