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首页> 外文期刊>British Journal of Cancer >HLA antigens in colorectal tumours — low expression of HLA class I antigens in mucinous colorectal carcinomas
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HLA antigens in colorectal tumours — low expression of HLA class I antigens in mucinous colorectal carcinomas

机译：大肠肿瘤中的HLA抗原-粘液性大肠癌中HLA I类抗原的低表达

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Expression of HLA antigens and beta 2-microglobulin was studied by immunoperoxidase staining of frozen sections of 9 mucinous and 10 nonmucinous colorectal adenocarcinomas, 1 cloacogenic carcinoma, 12 colorectal adenomas and 4 samples of normal colorectal mucosa using monoclonal antibodies (MAbs). Staining results were related to histopathological features. HLA Class I antigens were strongly expressed in morphologically normal colorectal epithelium, in all adenomas tested and in all non-mucinous carcinomas. In contrast, expression of HLA class I antigens by the majority of tumour cells was present in only 2 of the 9 mucinous carcinomas, whereas 2 of these mucinous carcinomas were completely negative. In the mucinous carcinomas a striking scarcity of mononuclear inflammatory infiltrate, especially around the mucus accumulations, was observed. HLA class II antigen expression was not detected in normal epithelium and was only focally present in 1 of the 12 adenomas. In 6 out of the 20 carcinomas tested between 20% and 90% of the tumour cells were stained by MAbs against HLA class II antigens. Apart from the low expression of HLA class I antigens in mucinous carcinomas no relationship was found between expression of HLA antigens and histological features of the tumours. The relative poor prognosis of mucinous colorectal carcinoma as reported in the literature may be associated with low expression of HLA class I antigens and scant mononuclear inflammatory infiltrate, which may be a reflection of a weak immune response to the tumour cells.
机译：使用单克隆抗体（MAb），通过免疫过氧化物酶染色法对9株粘液性和10株非粘液性结直肠腺癌，1例致癌性癌，12例结直肠腺瘤和4例正常结直肠粘膜样本的冷冻切片进行了免疫过氧化物酶染色，研究了HLA抗原和β2-微球蛋白的表达。染色结果与组织病理学特征有关。 HLA I类抗原在形态正常的结直肠上皮，所有测试的腺瘤和所有非粘液性癌中均强烈表达。相反，大多数肿瘤细胞表达的HLA I类抗原仅存在于9个粘液癌中的2个，而这些粘液癌中的2个完全阴性。在粘液癌中，观察到明显缺乏的单核炎性浸润物，特别是在粘液堆积物周围。在正常上皮中未检测到HLA II类抗原表达，仅在12个腺瘤中的1个中局部存在。在所测试的20种癌症中，有6种被20％至90％的肿瘤细胞用抗HLA II类抗原的单克隆抗体染色。除了在粘液癌中HLA I类抗原的低表达外，在HLA抗原的表达与肿瘤的组织学特征之间未发现任何关系。文献中报道的粘液性大肠癌预后相对较差可能与HLA I类抗原的低表达和单核炎性浸润少有关，这可能反映了对肿瘤细胞的免疫反应较弱。

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