...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Journal of Cancer >Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial
【24h】

Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial

机译：接受放疗的头颈癌患者口腔粘膜炎和口腔菌群的选择性消除：一项双盲随机临床试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mucositis is an acute inflammation of the oral mucosa because of radiotherapy and/or chemotherapy. All patients receiving radiotherapy in the head and neck region develop oral mucositis. The aim of this study was to analyse the effects of selective oral flora elimination on radiotherapy-induced oral mucositis, in a double-blind, randomised, placebo-controlled trial. Sixty-five patients with a malignant tumour in the head and neck regions to be treated with primary curative or postoperative radiotherapy participated in this study. The patients received either the active lozenges of 1?g containing polymyxin E 2?mg, tobramycin 1.8?mg and amphotericin B 10?mg (PTA) (33 patients) or the placebo lozenges (32 patients), four times daily during the full course of radiotherapy. Mucositis, changes in the oral flora, quality of feeding and changes of total body weight were assessed. Mucositis score did not differ between the groups during the first 5 weeks of radiotherapy. Nasogastric tube feeding was needed in six patients (19%) of the placebo group and two patients (6%) of the PTA group (P=0.08). Mean weight loss after 5 weeks of radiation was less in the PTA group (1.3?kg) (s.d.: 3.0) than in the placebo group (2.8?kg) (s.d.: 2.9) (P=0.05). Colonisation index of Candida species and Gram-negative bacilli was reduced in the PTA group and not in the placebo group (P<0.05). No effect on other microorganisms was detected. In conclusion, selective oral flora elimination in head and neck irradiation patients does not prevent the development of severe mucositis.
机译：粘膜炎是由于放疗和/或化学疗法引起的口腔粘膜的急性炎症。所有在头部和颈部区域接受放射治疗的患者都会发生口腔粘膜炎。这项研究的目的是在一项双盲，随机，安慰剂对照试验中分析选择性清除口腔菌群对放疗引起的口腔黏膜炎的影响。 65例头颈部恶性肿瘤患者需接受原发性治愈或术后放射治疗。患者在全服期间每天四次接受1毫克含多粘菌素E 2毫克，妥布霉素1.8毫克和两性霉素B 10毫克（PTA）的活性锭剂（33例）或安慰剂锭剂（32例）。放疗过程。评估了粘膜炎，口腔菌群的变化，喂养质量和总体重的变化。放疗的前5周，两组之间的粘膜炎评分没有差异。安慰剂组的六名患者（19％）和PTA组的两名患者（6％）需要鼻胃管喂养（P = 0.08）。 PTA组放疗后5周的平均体重减轻（1.3？kg）（标准剂量：3.0）低于安慰剂组（2.8？kg）（标准剂量：2.9）（P = 0.05）。 PTA组念珠菌和革兰氏阴性菌的定殖指数降低，而安慰剂组则没有（P <0.05）。未检测到对其他微生物的影响。总之，在头颈照射患者中选择性清除口腔菌群并不能预防严重的粘膜炎的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号