A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma

A R Clamp; F H Blackhall; P Vasey; M Soukop; R Coleman; G Halbert; L Robson; G C Jayson

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A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma

机译：每周24小时输注治疗复发性上皮性卵巢癌的bryostatin-1的II期试验

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Bryostatin-1 is a macrocyclic lactone whose main mechanism of action is protein kinase C modulation. We investigated its activity as a weekly 24-h infusion in recurrent ovarian carcinoma. In all, 17 patients were recruited and 11 had chemotherapy-resistant disease as defined by disease progression within 4 months of last cytotoxic therapy. All were evaluable for toxicity and 14 for response. There were no disease responses and the main toxicity was myalgia.

机译：Bryostatin-1是一种大环内酯，其主要作用机理是蛋白激酶C调节。我们调查了其在复发性卵巢癌中每周24小时输注的活性。总共招募了17名患者，其中11名患有最后一次细胞毒性治疗后4个月内疾病进展所定义的化疗耐药性疾病。所有这些药物的毒性均可以评估，而其响应度则为14。没有疾病反应，主要毒性是肌痛。

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《British Journal of Cancer》 |2003年第7期|共3页
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A R Clamp; F H Blackhall; P Vasey; M Soukop; R Coleman; G Halbert; L Robson; G C Jayson;
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中图分类肿瘤学;
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4. Effects of Weekly Paclitaxel as a Second-Iine Anticancer Chemotherapy for Patients with Advanced and Recurrent Gastric Carcinoma [C] . Y. Sakurai, I. Yoshida, T. Masui, International Gastric Cancer Congress . 2005

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5. The Use Of Carboplatin and Cyclosporin A In The Treatment of Recurrent Epithelial Ovarian Cancer. [D] . Overton, Eve. 2016

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6. A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma [O] . A R Clamp, F H Blackhall, P Vasey, 2003

机译：每周24小时输注治疗复发性上皮性卵巢癌的bryostatin-1的II期试验
7. A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma [O] . Clamp, A R, Blackhall, F H, Vasey, P, 2003

机译：每周24小时输注治疗复发性上皮性卵巢癌的bryostatin-1的II期试验

A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma

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