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首页> 外文期刊>British Journal of Cancer >Development and economic trends in cancer therapeutic drugs: a 5-year update 2010–2014
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Development and economic trends in cancer therapeutic drugs: a 5-year update 2010–2014

机译：癌症治疗药物的发展和经济趋势：2010-2014年的5年更新

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Background: Over the past 20 years, the mechanisms of action, duration of benefits and economic costs of newly licenced cancer drugs have changed significantly; however, summary data on these characteristics are limited. Methods: In this study, using historical copies of the British National Formulary and relevant contemporary publications, we have documented for each new cancer drug the year of introduction, therapeutic classification, initial indication, median duration of treatment and the cost of treatment at introduction relative to the then current UK GDP per capita. Results: Before 2000, there were 69 cancer treatment drugs available, of which 50 (72.5%) were classical cytotoxic drugs. In the subsequent 15 years, there have been 63 more new cancer treatment drugs added, including 20 kinase inhibitors and 11 monoclonal antibodies. The average median duration of treatment with a new drug has risen from 181 days in 1995–1999 to 263 days in 2010–2014. The average cost of treatment has also risen from ￡3036.91 (20.6% of UK per capita GDP) in 1995–1999 to ￡20?233 (89.0%) in 2005–2009 and now to ￡35?383 (141.7%) in 2010–2014. Conclusions: The last 5 years has seen 33 new cancer drugs. These drugs deliver significant benefits in patient outcomes and are taken for increasing lengths of time. Alongside these clinical benefits, the direct costs of new treatments have increased significantly over the past decade.
机译：背景：在过去的20年中，新许可的抗癌药物的作用机理，受益期限和经济成本发生了巨大变化;但是，有关这些特征的摘要数据是有限的。方法：在这项研究中，我们使用了英国国家处方集的历史副本和相关的当代出版物，为每种新的癌症药物记录了引入年份，治疗分类，初始适应症，中位治疗时间和引入时的治疗费用到当时的英国人均GDP。结果：在2000年之前，已有69种癌症治疗药物可供使用，其中50种（72.5％）是经典的细胞毒性药物。在随后的15年中，又增加了63种新的癌症治疗药物，包括20种激酶抑制剂和11种单克隆抗体。新药的平均治疗时间中位数已从1995-1999年的181天增加到2010-2014年的263天。平均治疗费用也从1995-1999年的3036.91英镑（占英国人均GDP的20.6％）上升到2005-2009的233英镑（占人均GDP的89.0％）和现在的35 383英镑（141.7％）。 –2014年。结论：过去5年中已经出现了33种新的抗癌药物。这些药物可为患者的预后带来显着的益处，并且可以延长治疗时间。除了这些临床益处之外，在过去的十年中，新疗法的直接费用已大大增加。

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