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首页> 外文期刊>British Journal of Cancer >Frequency and prognostic significance of p16 INK4A protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma
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Frequency and prognostic significance of p16 INK4A protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma

机译：p16 INK4A 蛋白过表达和转录活性人乳头瘤病毒感染在喉鳞状细胞癌中的发生频率和预后意义

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Background: Human papillomavirus (HPV) infection is a powerful prognostic biomarker in a subset of head and neck squamous cell carcinomas, specifically oropharyngeal cancers. However, the role of HPV in non-oropharyngeal sites, such as the larynx, remains unconfirmed. Methods: We evaluated a cohort of 324 laryngeal squamous cell carcinoma (LSCC) patients for the expression of p16~(INK4A)(p16) protein by immunohistochemistry (IHC) and for high-risk HPV E6 and E7 mRNA transcripts by RNA in situ hybridisation (ISH). p16 expression and HPV status were correlated with clinicopathological features and outcomes. Results: Of 307 patients assessable for p16 IHC, 20 (6.5%) were p16 positive. Females and node-positive patients were more likely to be p16 positive ( P <0.05). There were no other significant clinical or demographic differences between p16-positive and -negative cases. There was no difference in overall survival (OS) between p16-positive and -negative patients with 2-year survival of 79% in each group (HR=0.83, 95% CI 0.36–1.89, P =0.65). There was no statistically significant difference in failure-free survival (FFS) with 2-year FFS of 79% and 66% for p16-positive and -negative patients, respectively (HR=0.60, 95% CI 0.26–1.36, P =0.22). Only seven cases were found to be HPV RNA ISH positive, all of which were p16 IHC positive. There was no statistically significant difference in OS between patients with HPV RNA ISH-positive tumours compared with -negative tumours with 2-year survival of 86% and 71%, respectively (HR=0.76, 95% CI 0.23–2.5, P =0.65). The 2-year FFS was 86% and 59%, respectively (HR=0.62, 95% CI 0.19–2.03, P =0.43). Conclusions: p16 overexpression is infrequent in LSCC and the proportion of cases with high-risk HPV transcripts is even lower. There are no statistically significant correlations between p16 IHC or HPV RNA ISH status and OS or disease outcomes.
机译：背景：人乳头瘤病毒（HPV）感染是一部分头颈鳞状细胞癌，特别是口咽癌的有力预后生物标志物。但是，HPV在非口咽部位（如喉部）中的作用仍不确定。方法：我们评估了324例喉鳞状细胞癌（LSCC）患者的免疫组化（IHC）表达p16〜（INK4A）（p16）蛋白以及RNA原位杂交检测高危HPV E6和E7 mRNA转录本（ISH）。 p16表达和HPV状态与临床病理特征和预后相关。结果：在307位可评估p16 IHC的患者中，有20位（6.5％）为p16阳性。女性和淋巴结阳性患者更有可能是p16阳性（P <0.05）。 p16阳性和阴性病例之间没有其他明显的临床或人口统计学差异。 p16阳性和阴性患者的总生存期（OS）没有差异，每组的2年生存率分别为79％（HR = 0.83，95％CI 0.36-1.89，P = 0.65）。 p16阳性和阴性患者的2年FFS分别为79％和66％，无失败生存率（FFS）差异无统计学意义（HR = 0.60，95％CI 0.26-1.36，P = 0.22 ）。仅发现7例HPV RNA ISH阳性，所有均为p16 IHC阳性。 HPV RNA ISH阳性的患者与2年生存率分别为86％和71％的阴性患者之间的OS差异无统计学意义（HR = 0.76、95％CI 0.23–2.5，P = 0.65 ）。 2年FFS分别为86％和59％（HR = 0.62，95％CI 0.19–2.03，P = 0.43）。结论：LSCC很少发生p16过度表达，高危HPV转录本病例的比例更低。 p16 IHC或HPV RNA ISH状态与OS或疾病结局之间无统计学意义的相关性。

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