Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology

Margaret GKeane; Matthew THuggett; Michael HChapman; Gavin JJohnson; George JWebster; DouglasThorburn; JamesMackay; and Stephen PPereira

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Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology

机译：通过胆道刷细胞学检测微小染色体维持蛋白5诊断胰腺胆道恶性肿瘤

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Background:Biliary brush cytology is the standard method of evaluating biliary strictures, but is insensitive at detecting malignancy. In pancreaticobiliary cancer minichromosome maintenance replication proteins (MCM 2–7) are dysregulated in the biliary epithelium and MCM5 levels are elevated in bile samples. This study aimed to validate an immunocolorimetric ELISA assay for MCM5 as a pancreaticobiliary cancer biomarker in biliary brush samples.

机译：背景：胆道刷细胞学是评估胆道狭窄的标准方法，但对恶性肿瘤检测不敏感。在胰腺胆道癌中，微型染色体维持复制蛋白（MCM 2-7）在胆管上皮中失调，胆汁样本中MCM5水平升高。这项研究旨在验证MCM5作为胆汁刷样品中胰腺胆道癌生物标志物的免疫比色ELISA分析。

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《British Journal of Cancer》 |2017年第3期|共7页
作者
Margaret GKeane; Matthew THuggett; Michael HChapman; Gavin JJohnson; George JWebster; DouglasThorburn; JamesMackay; and Stephen PPereira;
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中图分类肿瘤学;
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专利

1. DIAGNOSIS OF PANCREATICOBILIARY MALIGNANCY BY DETECTION OF MINICHROMOSOME MAINTENANCE PROTEIN 5 IN BILIARY BRUSH CYTOLOGY SPECIMENS [J] . Gut: Journal of the British Society of Gastroenterology . 2009,第Suppla1期

机译：通过检测胆红素细胞学标本中的微小染色体维持蛋白5来诊断胰腺癌
2. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates [J] . L Ayaru, K Stoeber, G J Webster, British Journal of Cancer . 2008,第9期

机译：通过检测胆汁抽吸物中的微染色体维持蛋白5诊断胰腺胆道恶性肿瘤
3. KOC (K homology domain containing protein overexpressed in cancer) and S100A4-protein immunoreactivity improves the diagnostic sensitivity of biliary brushing cytology for diagnosing pancreaticobiliary malignancies. [J] . Ligato S, Zhao H, Mandich D, Diagnostic cytopathology . 2008,第8期

机译：KOC（含有在癌症中过表达的蛋白质的K同源结构域）和S100A4蛋白的免疫反应性可提高胆道刷洗细胞学对胰腺胆道恶性肿瘤诊断的敏感性。
4. Diagnosis of bladder cancer by Detection of survivin and minichromosome maintenance 5 protein in urine sediments [C] . First Zhengzhou International Oncology Congress（ZIOC）- An Update on Diagnosis and Treatment of Solid Tumors, 2005 . 2005

机译：通过检测尿沉渣中存活蛋白和微小染色体维持5蛋白来诊断膀胱癌
5. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology [O] . Margaret G Keane, Matthew T Huggett, Michael H Chapman, 2017

机译：通过胆道刷细胞学检测微染色体维持蛋白5诊断胰腺胆道恶性肿瘤
6. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology [O] . Margaret G Keane, Matthew T Huggett, Michael H Chapman, 2017

机译：通过检测胆汁血液卷曲细胞学中的微微体组维持蛋白5的诊断胰腺炎恶性肿瘤

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology

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