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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Prevalence of anti-thyroid peroxidase antibodies in serum in the elderly: comparison with other tests for anti-thyroid antibodies.
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Prevalence of anti-thyroid peroxidase antibodies in serum in the elderly: comparison with other tests for anti-thyroid antibodies.

机译：老年人血清中抗甲状腺过氧化物酶抗体的患病率：与其他抗甲状腺抗体检测方法的比较。

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Autoimmune thyroid disease, especially chronic thyroiditis, is prevalent in elderly women and is probably the major cause of hypothyroidism in this population. The reported prevalence of chronic thyroiditis is variable, depending on the area of residence and the method(s) used to detect the presence of anti-thyroid antibodies. The recent finding that thyroid peroxidase (TPO) is the antigen for the thyroid anti-microsomal antibody (AbM) has resulted in the development of sensitive radioimmunoassays (RIA) to detect the presence of AbTPO. We have determined the prevalence of AbTPO (by RIA) in sera from 342 elderly subjects, 248 women and 94 men (mean age 80 years) residing in Reggio Emilia, Italy, and compared the results with other methods for detecting anti-thyroid antibodies, including anti-thyroglobulin (AbTg) and AbM measured by passive hemagglutination (PH) of tanned erythrocytes, and AbM measured by RIA. The prevalence of positive AbTPO was 2.3% in the men and 10.2% in the women, only slightly higher than the prevalence of AbM. However, in the antibody-positive sera, the mean value for AbTPO was approximately 20-fold greater than the upper limit of the normal range, whereas the mean value for AbM was only threefold greater. The prevalence of positive titers for AbM and AbTg measured by PH was far lower, 1.2% and 3.2%, respectively, and those sera weakly positive for AbM and AbTg by PH were strongly positive for AbTPO by RIA. AbTPO RIA may be more useful than AbM and AbTg hemagglutination and AbM RIA for detecting the presence of autoimmune thyroid disease.
机译：自身免疫性甲状腺疾病，尤其是慢性甲状腺炎，在老年妇女中很普遍，可能是该人群甲状腺功能低下的主要原因。所报告的慢性甲状腺炎患病率是可变的，具体取决于居住地区和用于检测抗甲状腺抗体存在的方法。甲状腺过氧化物酶（TPO）是甲状腺抗微粒体抗体（AbM）的抗原的最新发现导致了开发灵敏的放射免疫分析（RIA）来检测AbTPO的存在。我们确定了意大利雷焦艾米利亚的342位老年受试者，248位女性和94位男性（平均年龄80岁）的血清中AbTPO（通过RIA）的患病率，并将结果与​​其他检测抗甲状腺抗体的方法进行了比较，包括通过鞣制红细胞的被动血凝（PH）测量的抗甲状腺球蛋白（AbTg）和AbM，以及通过RIA测量的AbM。男性AbTPO阳性的患病率为2.3％，女性为10.2％，仅略高于AbM的患病率。但是，在抗体阳性血清中，AbTPO的平均值比正常范围的上限大约高20倍，而AbM的平均值仅高三倍。用PH测定的AbM和AbTg阳性滴度的发生率要低得多，分别为1.2％和3.2％，而用PH测定的对AbM和AbTg弱阳性的血清用RIA对AbTPO很强。 AbTPO RIA在检测自身免疫性甲状腺疾病方面可能比AbM和AbTg血凝和AbM RIA更有用。

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