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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Falsely High Serum Free Triiodothyronine and Free Thyroxine Concentrations Attributable to Anti-Diiodothyronine and Anti-Triiodothyronine Antibodies
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Falsely High Serum Free Triiodothyronine and Free Thyroxine Concentrations Attributable to Anti-Diiodothyronine and Anti-Triiodothyronine Antibodies

机译：高血清游离三碘甲状腺素和游离甲状腺素浓度归因于抗二碘甲状腺素和抗三碘甲状腺素抗体

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We observed a patient with markedly increased free triiodothyronine (FT3) and free thyroxine (FT4) concentrations measured on a Vitros ECi analyzer (Ortho Clinical Diagnostics). The patient was a hospitalized 42-year-old woman with lupus erythematosus who appeared euthyroid and had normal thyroid-stimulating hormone (TSH) concentrations (Table 1 in the Data Supplement that accompanies the online version of this letter at http://www.clinchem.org/content/vol51/issue6/). Thyroid peroxidase antibody and thyroglobulin antibody were 0.3 kilounits/L, and rheumatoid factor was 6.0 kilounits/L. We suspected interference from heterophilic antibodies (1)(2), but our experiments suggested interference from antibodies to diiodothyronine (T2), T3, or their conjugates, as have been described (3)(4)(5). The procedures in this study were in accordance with the Helsinki Declaration of 1975 and the subsequent 1996 amendments.In contrast to results of the Vitros ECi FT3 and FT4 assays, which use solid phases with T2- and T3-gelatin, respectively, and labeled sheep antibodies, FT3 and FT4 were normal by the Elecsys assays (Roche Diagnostics), which use biotinylated antibodies in a one-step …
机译：我们观察到在Vitros ECi分析仪（Ortho Clinical Diagnostics）上测得的患者的游离三碘甲状腺素（FT3）和游离甲状腺素（FT4）浓度明显增加。该患者是一名住院的42岁女性，患有红斑狼疮，表现出甲状腺功能正常，甲状腺刺激激素（TSH）浓度正常（《数据补充》中的表1，该信的在线版本位于http：// www。 clinchem.org/content/vol51/issue6/）。甲状腺过氧化物酶抗体和甲状腺球蛋白抗体＜0.3千单位/升，类风湿因子＜6.0千单位/升。我们怀疑来自嗜异性抗体（1）（2）的干扰，但我们的实验表明抗体对二碘甲甲状腺氨酸（T2），T3或其结合物的干扰，如已描述的（3）（4）（5）。这项研究的程序符合1975年的《赫尔辛基宣言》和随后的1996年修正案，与Vitros ECi FT3和FT4分析的结果形成鲜明对比，后者分别使用T2-和T3-明胶和标记羊的固相Elecsys分析法（罗氏诊断公司（Roche Diagnostics））的抗体，FT3和FT4抗体是正常的，它们一步一步使用生物素化抗体...

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