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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Plasma Vitamin B6 Vitamers before and after Oral Vitamin B6 Treatment: A Randomized Placebo-controlled Study
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Plasma Vitamin B6 Vitamers before and after Oral Vitamin B6 Treatment: A Randomized Placebo-controlled Study

机译：口服维生素B6治疗前后的血浆维生素B6维生素：一项随机安慰剂对照研究

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Background: Vitamin B6 has attracted renewed interest because of its role in homocysteine metabolism and its possible relation to cardiovascular risk. We examined the plasma B6 vitamers, pyridoxal 5′-phosphate (PLP), pyridoxal (PL), pyridoxine (PN), and 4-pyridoxic acid (4-PA) before and after vitamin B6 supplementation.Methods: Patients (n = 90; age range, 38–80 years) undergoing coronary angiography (part of the homocysteine-lowering Western Norway B-Vitamin Intervention Trial) were allocated to the following daily oral treatment groups: (A), vitamin B12 (0.4 mg), folic acid (0.8 mg), and vitamin B6 (40 mg); (B), vitamin B12 and folic acid; (C), vitamin B6; or (D), placebo. EDTA blood was obtained before treatment and 3, 14, 28, and 84 days thereafter.Results: Before treatment, PLP (range, 5–111 nmol/L) and 4-PA (6–93 nmol/L) were the predominant B6 vitamers identified in plasma. During the 84-day study period, the intraindividual variation (CV) in patients not treated with vitamin B6 (groups B and D) was 45% for PLP and 67% for 4-PA. Three days after the start of treatment, the increases in concentration were ～10-, 50-, and 100-fold for PLP, 4-PA, and PL, respectively. No significant additional increase was observed at the later time points. The PLP concentration correlated to the concentrations of 4-PA and PL before treatment, but not after treatment. The PL concentration correlated with 4-PA before and after treatment.Conclusions: Vitamin B6 treatment has an immediate effect on the concentrations and the forms of B6 vitamers present in plasma, and the changes remain the same during prolonged treatment. Our results suggest that the B6 vitamers in plasma reflect vitamin B6 intake.
机译：背景：维生素B6在同型半胱氨酸代谢中的作用及其与心血管风险的可能关系引起了人们的新兴趣。我们在补充维生素B6之前和之后检查了血浆B6维生素，吡ido醛5'-磷酸（PLP），吡ido醛（PL），吡ido醇（PN）和4-吡啶氧酸（4-PA）。方法：患者（n = 90 ;年龄在38-80岁之间的患者接受冠状动脉造影（降低同型半胱氨酸的挪威西部B-维生素干预试验的一部分），分为以下每日口服治疗组：（A），维生素B12（0.4毫克），叶酸（0.8毫克）和维生素B6（40毫克）; （二），维生素B12和叶酸; （C），维生素B6;或（D），安慰剂。治疗前以及治疗后3、14、28和84天获得EDTA血。结果：治疗前，主要的B6为PLP（5-111 nmol / L）和4-PA（6-93 nmol / L）。在血浆中鉴定出的维生素。在为期84天的研究期内，未接受维生素B6治疗的患者（B和D组）的车内个体差异（CV）对于PLP为45％，对于4-PA为67％。治疗开始三天后，PLP，4-PA和PL的浓度分别增加了约10倍，50倍和100倍。在以后的时间点没有观察到明显的额外增加。 PLP浓度与治疗前而不是治疗后4-PA和PL的浓度相关。结论：维生素B6治疗对血浆中B6维他命的浓度和形式有直接的影响，延长治疗后其变化保持不变。我们的结果表明血浆中的B6维生素反映了维生素B6的摄入量。

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