...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Critical care : >Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study
【24h】

Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study

机译：脑膜炎双球菌败血症基础缺陷分配方法的验证：一项回顾性研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

IntroductionThe base deficit is a useful tool for quantifying total acid–base derangement, but cannot differentiate between various aetiologies. The Stewart–Fencl equations for strong ions and albumin have recently been abbreviated; we hypothesised that the abbreviated equations could be applied to the base deficit, thus partitioning this parameter into three components (the residual being the contribution from unmeasured anions).MethodsThe two abbreviated equations were applied retrospectively to blood gas and chemistry results in 374 samples from a cohort of 60 children with meningococcal septic shock (mean pH 7.31, mean base deficit -7.4 meq/L). Partitioning required the simultaneous measurement of plasma sodium, chloride, albumin and blood gas analysis.ResultsAfter partitioning for the effect of chloride and albumin, the residual base deficit was closely associated with unmeasured anions derived from the full Stewart–Fencl equations (r2 = 0.83, y = 1.99 – 0.87x, standard error of the estimate = 2.29 meq/L). Hypoalbuminaemia was a common finding; partitioning revealed that this produced a relatively consistent alkalinising effect on the base deficit (effect +2.9 ± 2.2 meq/L (mean ± SD)). The chloride effect was variable, producing both acidification and alkalinisation in approximately equal proportions (50% and 43%, respectively); furthermore the magnitude of this effect was substantial in some patients (SD ± 5.0 meq/L).ConclusionIt is now possible to partition the base deficit at the bedside with enough accuracy to permit clinical use. This provides valuable information on the aetiology of acid–base disturbance when applied to a cohort of children with meningococcal sepsis.
机译：简介碱缺乏是定量酸碱总失序的有用工具，但不能区分各种病因。最近已经简化了有关强离子和白蛋白的Stewart-Fencl方程。我们假设可以将简化的方程式应用于基本亏缺，从而将该参数划分为三个部分（残差是未测阴离子的贡献）。 60例脑膜炎球菌败血性休克患儿队列（平均pH值为7.31，平均碱缺乏-7.4 meq / L）。分区需要同时测量血浆钠，氯，白蛋白和血气分析。结果在对氯和白蛋白的影响进行分区后，残留的碱缺乏与从完整的Stewart-Fencl方程（r2 = 0.83， y = 1.99 – 0.87x，估算的标准误= 2.29 meq / L）。低白蛋白血症是一个常见的发现。分配显示这对碱缺乏产生了相对一致的碱化作用（效果+2.9±2.2 meq / L（平均值±SD））。氯化物的作用是可变的，以大约相等的比例（分别为50％和43％）产生酸化作用和碱化作用。此外，在某些患者中，这种作用的程度相当大（SD±5.0 meq / L）。结论现在可以在床旁以足够的准确度分配基础缺失，以允许临床使用。当将其应用于脑膜炎球菌败血症患儿队列时，这为酸碱紊乱的病因学提供了有价值的信息。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号