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首页> 外文期刊>Critical care : >In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
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In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance

机译：在中心静脉导管中同时施用不相容药物且端口间距离减小的体内评估

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Background:Multilumen catheters are commonly used in critically ill children.Their use, however, is associated with significant morbidity. We studied thesimultaneous administration of incompatible drugs using a new triple-lumencatheter with decreased length and port to port distances.Methods:Ten domestic swine, 10–20 kg in weight, were divided into twogroups of five. Total parenteral nutrition was administered through the distalport and phenytoin was administered as a bolus and as an infusion in eachgroup. Samples were taken from two sites during the bolus and at 1, 5, and15 min during phenytoin infusion. Histograms were generated for particle sizeand concentration. Samples were also examined under the microscope forparticles.Results:Histograms of particle size did not show any alteration of thehistogram that would suggest particle size > 2 μm in diameter in thestudy or control samples. No particles were identified by phase microscope,light microscope, or Wright stain smear.Conclusions:The use of a triple-lumen catheter with a distance of 0.4cmbetween the proximal port and the medial port and 1.3 cm between the medial portand the distal port, for the in vivo simultaneous administration ofincompatible solutions does not result in precipitates large enough to causeadverse clinical effects.
机译：背景：多腔导管通常用于重症儿童，但是使用它们会导致高发病率。我们研究了使用新的三腔导管同时减少长度和端口到端口距离的同时服用不相容药物的方法。方法：将十只体重10–20 kg的家猪分成两组，每组五个。通过末梢口给予总肠胃外营养，并在每组中以大剂量和输注方式给予苯妥英。在推注期间和苯妥英钠输注期间的1、5和15分钟时从两个位置取样。生成直方图以了解粒度和浓度。结果：粒径直方图没有显示任何直方图的变化，这表明研究或对照样品中的粒径大于2μm。结论：使用三腔导管，近端端口和内侧端口之间的距离为0.4cm，而内侧端口和远端端口之间的距离为1.3cm，在体内同时施用不相容溶液时，不会产生足够大的沉淀物以引起不良的临床影响。

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