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首页> 外文期刊>Critical care : >Feasibility study on full closed-loop control ventilation (IntelliVent-ASV?) in ICU patients with acute respiratory failure: a prospective observational comparative study
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Feasibility study on full closed-loop control ventilation (IntelliVent-ASV?) in ICU patients with acute respiratory failure: a prospective observational comparative study

机译：ICU急性呼吸衰竭患者完全闭环通气（IntelliVent-ASV ？）的可行性研究：一项前瞻性观察性比较研究

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IntroductionIntelliVent-ASV? is a full closed-loop ventilation mode that automatically adjusts ventilation and oxygenation parameters in both passive and active patients. This feasibility study compared oxygenation and ventilation settings automatically selected by IntelliVent-ASV? among three predefined lung conditions (normal lung, acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD)) in active and passive patients. The feasibility of IntelliVent-ASV? use was assessed based on the number of safety events, the need to switch to conventional mode for any medical reason, and sensor failure.MethodThis prospective observational comparative study included 100 consecutive patients who were invasively ventilated for less than 24 hours at the time of inclusion with an expected duration of ventilation of more than 12 hours. Patients were ventilated using IntelliVent-ASV? from inclusion to extubation. Settings, automatically selected by the ventilator, delivered ventilation, respiratory mechanics, and gas exchanges were recorded once a day.ResultsRegarding feasibility, all patients were ventilated using IntelliVent-ASV? (392 days in total). No safety issues occurred and there was never a need to switch to an alternative ventilation mode. The fully automated ventilation was used for 95% of the total ventilation time. IntelliVent-ASV? selected different settings according to lung condition in passive and active patients. In passive patients, tidal volume (VT), predicted body weight (PBW) was significantly different between normal lung (n = 45), ARDS (n = 16) and COPD patients (n = 19) (8.1 (7.3 to 8.9) mL/kg; 7.5 (6.9 to 7.9) mL/kg; 9.9 (8.3 to 11.1) mL/kg, respectively; P 0.05). In passive ARDS patients, FiO2 and positive end-expiratory pressure (PEEP) were statistically higher than passive normal lung (35 (33 to 47)% versus 30 (30 to 31)% and 11 (8 to 13) cmH2O versus 5 (5 to 6) cmH2O, respectively; P< 0.05).ConclusionsIntelliVent-ASV? was safely used in unselected ventilated ICU patients with different lung conditions. Automatically selected oxygenation and ventilation settings were different according to the lung condition, especially in passive patients.Trial RegistrationClinicalTrials.gov: NCT01489085
机译：简介IntelliVent-ASV？是一种完全闭环通气模式，可自动调整被动和主动患者的通气和充氧参数。这项可行性研究比较了IntelliVent-ASV自动选择的充氧和通风设置？主动和被动患者的三种预定的肺部疾病（正常肺部，急性呼吸窘迫综合征（ARDS）和慢性阻塞性肺疾病（COPD））。 IntelliVent-ASV的可行性？方法根据安全事件的数量，出于任何医学原因需要切换至常规模式以及传感器故障的情况来评估使用情况。方法这项前瞻性观察性比较研究包括100例连续的患者，入院时其通气时间少于24小时预期通风时间超过12小时。使用IntelliVent-ASV为患者通气吗？从包容到拔管每天记录一次由呼吸机自动选择的设置，通气，呼吸力学和气体交换的结果。关于可行性，所有患者均使用IntelliVent-ASV进行了通气？ （总共392天）。不会发生安全问题，并且不需要切换到其他通风模式。全自动通风用于总通风时间的95％。 IntelliVent-ASV？根据被动和主动患者的肺部状况选择不同的设置。在被动患者中，正常肺部（n = 45），ARDS（n = 16）和COPD患者（n = 19）的潮气量（VT），预测体重（PBW）显着不同（8.1（7.3至8.9）mL / kg; 7.5（6.9至7.9）mL / kg; 9.9（8.3至11.1）mL / kg; P 0.05）。在被动性ARDS患者中，FiO2和呼气末正压（PEEP）在统计学上高于被动正常肺（35（33至47）％对30（30至31）％和11（8至13）cmH2O对5（5）至6）cmH2O; P <0.05）。可以安全地用于未经选择的具有不同肺部条件的ICU通气患者。根据肺部情况，自动选择的供氧和通气设置会有所不同，尤其是在被动患者中。Trial RegistrationClinicalTrials.gov：NCT01489085

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