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A prospective longitudinal multicentre study of health related quality of life in ICU survivors with COPD

机译：对患有COPD的ICU幸存者健康相关生活质量的前瞻性纵向多中心研究

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IntroductionMortality amongst COPD patients treated on the ICU is high. Health-related quality of life (HRQL) after intensive care is a relevant concern for COPD patients, their families and providers of health care. Still, there are few HRQL studies after intensive care of this patient group. Our hypothesis was that HRQL of COPD patients treated on the ICU declines rapidly with time.MethodsFifty-one COPD patients (COPD-ICU group) with an ICU stay longer than 24 hours received a questionnaire at 6, 12 and 24 months after discharge from ICU. HRQL was measured using two generic instruments: the EuroQoL instrument (EQ-5D and EQ-VAS) and the Short Form 36 Health Survey (SF-36). The results were compared to HRQL of two reference groups from the general population; an age- and sex-adjusted reference population (Non-COPD reference) and a reference group with COPD (COPD reference).ResultsHRQL of the COPD-ICU group at 6 months after discharge from ICU was lower compared to the COPD reference group: Median EQ-5D was 0.66 vs. 0.73, P = 0.08 and median EQ-VAS was 50 vs.55, P < 0.05. There were no significant differences in the SF-36 dimensions between the COPD-ICU and COPD-reference groups, although the difference in physical functioning (PF) approached statistical significance (P = 0.059). Patients in the COPD-ICU group who were lost to follow-up after 6 months had low HRQL scores at 6 months. Scores for patients who died were generally lower compared to patients who failed to respond to the questionnaire. The PF and social functioning (SF) scores in those who died were significantly lower compared to patients with a complete follow up. HRQL of patients in the COPD-ICU group that survived a complete 24 months follow up was low but stable with no statistically significant decline from 6 to 24 months after ICU discharge. Their HRQL at 24 months was not significantly different from HRQL in the COPD reference group.ConclusionsHRQL in COPD survivors after intensive care was low but did not decline from 6 to 24 months after discharge from ICU. Furthermore, HRQL at 24 months was similar to patients with COPD who had not received ICU treatment.
机译：简介在ICU上治疗的COPD患者的死亡率很高。重症监护后与健康有关的生活质量（HRQL）是COPD患者，他们的家人和医疗保健提供者的关注重点。仍然，在对该患者组进行重症监护后，HRQL研究很少。我们的假设是在ICU上接受治疗的COPD患者的HRQL随时间迅速下降。方法51位ICU停留时间超过24小时的COPD患者（COPD-ICU组）在ICU出院后6、12和24个月接受了问卷调查。 HRQL是使用两种通用工具进行测量的：EuroQoL工具（EQ-5D和EQ-VAS）和36型健康简表（SF-36）。将结果与普通人群中两个参考组的HRQL进行比较;结果：从ICU出院后6个月，COPD-ICU组的HRQL低于COPD参考组：中位数EQ-5D为0.66 vs.0.73，P = 0.08，中位数EQ-VAS为50 vs.55，P <0.05。尽管身体功能（PF）的差异接近统计学意义（P = 0.059），但COPD-ICU和COPD参照组之间的SF-36尺寸没有显着差异。 COPD-ICU组的患者在6个月后失去随访，但在6个月时HRQL评分较低。与未回答问卷的患者相比，死亡患者的分数通常较低。与完全随访的患者相比，死亡者的PF和社会功能（SF）得分明显较低。在ICU出院后6到24个月内，COPD-ICU组的患者在完整24个月的随访中存活下来的HRQL较低，但稳定，无统计学意义的下降。他们在24个月时的HRQL与COPD参照组中的HRQL并无显着差异。结论重症监护后COPD幸存者的HRQL较低，但从ICU出院后6到24个月并未下降。此外，在24个月时的HRQL与未接受ICU治疗的COPD患者相似。

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